Evidence map›Paper›PMID 40431728›Full record

ArticleViruses2025

Novel Orthohantavirus Associated with Hantavirus Pulmonary Syndrome in Northern Argentina.

Carla M Bellomo, Sebastian Kehl, Daniel Oscar Alonso, Walter López, Flavia Cassinelli, Rocío María Coelho, Gabriela Bravo, Sara Aguirre, Marcela Dib, Natalia Periolo and 5 more

Abstract readCase Reports
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Carla M BellomoInstituto Nacional de Enfermedades Infecciosas (INEI)-Administración Nacional de Laboratorios e Institutos de Salud (ANLIS) Malbran, Buenos Aires C1282, Argentina.ORCID 0000-0001-6869-1707
Sebastian KehlInstituto Nacional de Enfermedades Infecciosas (INEI)-Administración Nacional de Laboratorios e Institutos de Salud (ANLIS) Malbran, Buenos Aires C1282, Argentina.ORCID 0000-0003-1203-7225
Daniel Oscar AlonsoInstituto Nacional de Enfermedades Infecciosas (INEI)-Administración Nacional de Laboratorios e Institutos de Salud (ANLIS) Malbran, Buenos Aires C1282, Argentina.ORCID 0000-0003-3605-4679
Walter LópezInstituto de Investigaciones de Enfermedades Tropicales-IIET, Universidad Nacional de Salta (UNSa), Salta A4400, Argentina.ORCID 0000-0001-5677-3537
Flavia CassinelliInstituto de Ecorregiones Andinas (INECOA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Jujuy (UNJu), San Salvador de Jujuy Y4600, Argentina.ORCID 0009-0005-7010-1987
Rocío María CoelhoInstituto Nacional de Enfermedades Infecciosas (INEI)-Administración Nacional de Laboratorios e Institutos de Salud (ANLIS) Malbran, Buenos Aires C1282, Argentina.ORCID 0000-0002-7274-9315
Gabriela BravoHospital Señor Del Milagro, Salta A4400, Argentina.
Sara AguirreInstituto de Investigaciones en Energía No Convencional (INENCO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Salta (UNSa), Salta A4400, Argentina.ORCID 0009-0007-7521-6040
Marcela DibHospital Señor Del Milagro, Salta A4400, Argentina.
Natalia PerioloInstituto Nacional de Enfermedades Infecciosas (INEI)-Administración Nacional de Laboratorios e Institutos de Salud (ANLIS) Malbran, Buenos Aires C1282, Argentina.ORCID 0000-0002-2077-720X
Concepción ToscanoHospital Señor Del Milagro, Salta A4400, Argentina.
José GilInstituto de Investigaciones en Energía No Convencional (INENCO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Salta (UNSa), Salta A4400, Argentina.ORCID 0000-0003-3994-1265
Francisco García CamposDirección General de Coordinación Epidemiológica, Ministerio de Salud Pública de Salta, Salta A4400, Argentina.ORCID 0000-0002-9362-4933
Ignacio FerroInstituto de Ecorregiones Andinas (INECOA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Jujuy (UNJu), San Salvador de Jujuy Y4600, Argentina.ORCID 0000-0001-7022-4606
Valeria Paula MartinezInstituto Nacional de Enfermedades Infecciosas (INEI)-Administración Nacional de Laboratorios e Institutos de Salud (ANLIS) Malbran, Buenos Aires C1282, Argentina.ORCID 0000-0002-4356-8136

Funding

Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación PICT-2021-I-A-01199
6 · The paper itself

Abstract

In this work, we performed the genetic characterization of a new variant of orthohantavirus associated with a fatal case of hantavirus pulmonary syndrome, outside the known endemic region, in northwestern Argentina. We first confirmed an orthohantavirus infection by ELISA, testing for the detection of IgM and IgG antibodies. Then, we extracted RNA from 100 microliters of serum, the only sample available, followed by RT-PCR. The amplicons were sequenced using Sanger and next-generation sequencing technology. We obtained partial sequences of 1253 bp, 799 bp and 1675 bp from the S-, M- and L-segments, respectively, showing low sequence identities with all the previously characterized hantaviruses (10.9%, 13.5% and 15.1% of the divergence, respectively). The phylogenetic analysis showed that this virus belongs to the

Indexed as

Hantavirus Pulmonary SyndromeOrthohantavirusAnimalsAntibodies, ViralArgentinaEnzyme-Linked Immunosorbent AssayFemaleHigh-Throughput Nucleotide SequencingHumansImmunoglobulin GImmunoglobulin MMalePhylogenyRNA, ViralRodentiaSequence Analysis, DNAAntibodies, ViralImmunoglobulin GImmunoglobulin MRNA, ViralArgentinaGuachipashantavirus pulmonary syndromeinfectious diseasesorthohantavirusrodentsSaltazoonosis

Identifiers

PMID40431728
PMCPMC12116063

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.