Evidence map›Paper›PMID 40431719›Full record

ArticleViruses2025

Postnatal Epigenetic Alterations in Calves Persistently Infected with Bovine Viral Diarrhea Virus.

Jessica N Kincade, Dilyara A Murtazina, Hanah M Georges, Carolina L Gonzalez-Berrios, Jeanette V Bishop, Terry E Engle, Marcela Henao-Tamayo, Jordan M Eder, Erin M McDonald, Darcy M Deines and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jessica N KincadeDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0003-3699-699X
Dilyara A MurtazinaDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Hanah M GeorgesDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0001-9065-9885
Carolina L Gonzalez-BerriosDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Jeanette V BishopDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Terry E EngleDepartment of Animal Sciences, Colorado State University, Fort Collins, CO 80521, USA.
Marcela Henao-TamayoDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80521, USA.
Jordan M EderZoetis, Research Innovation Center, Fort Collins, CO 80523, USA.
Erin M McDonaldZoetis, Research Innovation Center, Fort Collins, CO 80523, USA.
Darcy M DeinesZoetis, Research Innovation Center, Fort Collins, CO 80523, USA.
Brie M WrightZoetis, Research Innovation Center, Fort Collins, CO 80523, USA.
Hana Van CampenDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0003-3100-9174
Thomas R HansenDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0001-7244-8769

Funding

National Institute of Food and Agriculture 2021-38420-34040National Institute of Food and Agriculture 2023-67011-40513National Institute of Food and Agriculture Hatch/Multi-State Research Fund Accession No. 1011648, W114 Project No. COLO0220CUnited States Department of Agriculture 2019-67015-29866
6 · The paper itself

Abstract

Bovine viral diarrhea virus (BVDV) is a globally prevalent pathogen causing severe detriment to the cattle industry. Vertical infection occurring before the development of the fetal adaptive immune response, before 125 days of gestation, results in an immunotolerant, persistently infected (PI) calf. It was hypothesized that epigenetic alterations observed in the splenic tissue of PI fetuses at gestational day 245 would persist into the postnatal period. White blood cell DNA from five PI and five control heifers at 4 months of age was subjected to reduced representation bisulfite sequencing and interpreted within the context of complete blood count and flow cytometry data herein. Analysis revealed 8367 differentially methylated sites contained within genes associated with the immune and cardiac system, as well as hematopoiesis. Differences observed in the complete blood counts of PI heifers include increased monocytes, microcytic anemia, and elevated platelets with decreased mean platelet volume. Flow cytometry revealed increased classical monocytes, B cells, and CD4

Indexed as

Bovine Virus Diarrhea-Mucosal DiseaseDiarrhea Viruses, Bovine ViralEpigenesis, GeneticPersistent InfectionAnimalsCattleDNA MethylationFemalePregnancySpleenbovine viral diarrhea virusepigenomicspersistent infection

Identifiers

PMID40431719
PMCPMC12115714

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.