Evidence map›Paper›PMID 40431716›Full record

ReviewViruses2025

Emerging Prognostic and Predictive Biomarkers for Human Cytomegalovirus Infection During Pregnancy: Unmet Needs and Future Perspectives.

Salvatore Rotundo, Maria Teresa Tassone, Rosaria Lionello, Paolo Fusco, Francesca Serapide, Alessandro Russo

Abstract readReview
In one paragraph

Review in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Salvatore RotundoInfectious Disease Unit, "San Giovanni di Dio" Hospital, 88900 Crotone, Italy.ORCID 0000-0001-5441-1727
Maria Teresa TassoneDepartment of Medical and Surgical Sciences, "Magna Graecia" University, 88100 Catanzaro, Italy.
Rosaria LionelloInfectious and Tropical Disease Unit, "Renato Dulbecco" Teaching Hospital, 88100 Catanzaro, Italy.
Paolo FuscoInfectious and Tropical Disease Unit, "Renato Dulbecco" Teaching Hospital, 88100 Catanzaro, Italy.ORCID 0000-0002-3949-4293
Francesca SerapideDepartment of Medical and Surgical Sciences, "Magna Graecia" University, 88100 Catanzaro, Italy.ORCID 0000-0002-5555-3732
Alessandro RussoDepartment of Medical and Surgical Sciences, "Magna Graecia" University, 88100 Catanzaro, Italy.ORCID 0000-0003-3846-4620

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) infection during pregnancy is a leading cause of congenital infections worldwide, posing significant risks to fetal health. Despite advances in prenatal care, managing HCMV infection remains challenging. Early detection, accurate risk assessment, and timely intervention are critical to mitigating the adverse outcomes associated with congenital HCMV (cHCMV), such as neurodevelopmental delays and hearing loss. However, the current landscape of biomarkers for HCMV infection in pregnancy is marked by several unmet needs. These gaps in biomarker development and application limit our ability to predict fetal transmission, assess the risk of fetal damage, and prognosticate long-term outcomes. Addressing these challenges through the identification and validation of novel biomarkers could revolutionize the management of HCMV in pregnancy, leading to improved outcomes for both mothers and their children. This review examines the critical unmet needs regarding HCMV biomarkers during pregnancy, emphasizing the priority areas for further research and innovation.

Indexed as

BiomarkersCytomegalovirusCytomegalovirus InfectionsPregnancy Complications, InfectiousFemaleHumansInfectious Disease Transmission, VerticalPregnancyPrognosisBiomarkersbiomarkersDNAemiaexosomesHCMVNIPTserologyT-cell response

Identifiers

PMID40431716
PMCPMC12115395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.