Evidence map›Paper›PMID 40431695›Full record

ArticleViruses2025

Higher Rates of Viral Evolution in Chronic Hepatitis B Patients Linked to Predicted T Cell Epitopes.

Magnus Illum Dalegaard, Anni Winckelmann, Ulrik Fahnøe, Alexander P Underwood, Anders Gorm Pedersen, Signe Bollerup, Jens Bukh, Nina Weis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Magnus Illum DalegaardDepartment of Infectious Diseases, Copenhagen University Hospital, 2650 Hvidovre, Denmark.
Anni WinckelmannDepartment of Infectious Diseases, Copenhagen University Hospital, 2650 Hvidovre, Denmark.
Ulrik FahnøeDepartment of Infectious Diseases, Copenhagen University Hospital, 2650 Hvidovre, Denmark.
Alexander P UnderwoodDepartment of Infectious Diseases, Copenhagen University Hospital, 2650 Hvidovre, Denmark.
Anders Gorm PedersenDepartment of Health Technology, Section for Bioinformatics, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.ORCID 0000-0001-9650-8965
Signe BollerupDepartment of Infectious Diseases, Copenhagen University Hospital, 2650 Hvidovre, Denmark.ORCID 0000-0001-9604-4582
Jens BukhDepartment of Infectious Diseases, Copenhagen University Hospital, 2650 Hvidovre, Denmark.ORCID 0000-0002-7815-4806
Nina WeisDepartment of Infectious Diseases, Copenhagen University Hospital, 2650 Hvidovre, Denmark.ORCID 0000-0002-3133-2724

Funding

Novo Nordisk Foundation BRIDGE research fellowship (APU)Novo Nordisk Foundation NNF19OC0054518 (JB) and NNF19OC0055462 (JB and NW)Sygeforsikringen "Danmark No. 2022-0265 (to JB)The Danish Cancer Society (Grant No. R325-A19151 (JB)).
6 · The paper itself

Abstract

The impact of hepatitis B virus (HBV) diversity and evolution on disease progression is not well-understood. This study aims to compare intra-individual viral evolution in two groups of chronic hepatitis B (CHB) patients, using antiviral treatment initiation as a measure of lack of immunological control. From the Danish Database for Hepatitis B and C (DANHEP), 25 CHB patients were included; 14 with antiviral treatment initiation (TI group), and 11 without (NTI group). For each patient, three serial plasma samples taken before potential treatment initiation were selected. HBV DNA was amplified by PCR and analyzed by next-generation sequencing. HBV DNA and alanine transaminase were elevated in the TI group throughout the study period. Significantly higher substitution rates in the NTI group versus the TI group were found both within the viral population and at consensus level. Putative predicted CD8

Indexed as

Epitopes, T-LymphocyteEvolution, MolecularHepatitis B, ChronicHepatitis B virusAdultAntiviral AgentsDNA, ViralFemaleGenome, ViralHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedPhylogenyAntiviral AgentsDNA, ViralEpitopes, T-LymphocyteDANHEPHBVmutation ratenext-generation sequencingT cell epitopes

Identifiers

PMID40431695
PMCPMC12115741

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.