Evidence map›Paper›PMID 40431679›Full record

ArticleViruses2025

Comprehensive Diagnosis of Viral Hepatitis in Spain: Bases for Implementation.

Joaquin Cabezas, Antonio Aguilera, Federico García, Raquel Domínguez-Hernández, Araceli Casado-Gómez, Nataly Espinoza-Cámac, Miguel Ángel Casado, Javier Crespo, Task Force Spanish Group for Comprehensive Hepatitis Diagnosis

Abstract read
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joaquin CabezasGastroenterology and Hepatology Service, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.ORCID 0000-0003-0012-484X
Antonio AguileraMicrobiology Service and Instituto de Investigación Sanitaria de Santiago (IDIS), University Clinical Hospital of Santiago de Compostela, 15706 A Coruña, Spain.ORCID 0000-0001-6940-241X
Federico GarcíaMicrobiology Service, San Cecilio Clinical University Hospital, 18007 Granada, Spain.ORCID 0000-0001-7611-781X
Raquel Domínguez-HernándezPharmacoeconomics & Outcomes Research Iberia (PORIB), 28224 Madrid, Spain.ORCID 0000-0003-1083-7288
Araceli Casado-GómezPharmacoeconomics & Outcomes Research Iberia (PORIB), 28224 Madrid, Spain.
Nataly Espinoza-CámacPharmacoeconomics & Outcomes Research Iberia (PORIB), 28224 Madrid, Spain.ORCID 0000-0002-8116-6963
Miguel Ángel CasadoPharmacoeconomics & Outcomes Research Iberia (PORIB), 28224 Madrid, Spain.ORCID 0000-0002-8743-6653
Javier CrespoGastroenterology and Hepatology Service, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.ORCID 0000-0001-8248-0172
Task Force Spanish Group for Comprehensive Hepatitis Diagnosis

Funding

Gilead Sciences (Spain) Gilead [IN-ES-980-6538, IDIVAL 2022-8959]
6 · The paper itself

Abstract

In 2022, scientific societies agreed on a document with recommendations for a comprehensive diagnosis of viral hepatitis (B, C, and D). The aim was to evaluate the situation in Spain regarding the comprehensive diagnosis of viral hepatitis in a single blood draw before it is recommended. A panel of experts prepared a structured survey directed at hospitals (public or private with teaching accreditation) with ≥200 beds (sent 20 October 2022, closed 1 December 2022). The response rate was 61% (79/129; 52 hospitals with >500 beds). Among the participating hospitals, all could perform tests for HBsAg, anti-HCV, and HIV serology; 94% could perform PCR testing for HCV, 63% could test for anti-HDV, and 28% could test for HDV-RNA (67% [53/79] outsourced this testing). Point-of-care (POC) testing availability was low (24%), with 84% of these tests being supervised by the reference microbiological laboratory and the results being registered in the patients' medical history. Ninety percent of the centers carried out the diagnosis in a single step (99% HCV, 70% HBV, 48% HDV, and 44% HBV-HDV). In addition, 77% used some communication strategy when an active infection was encountered (100% HCV, 49% HBV, and 31% HDV). Only 20% had an automated system for scheduling a specialist physician appointment. Most hospitals had the means for a comprehensive diagnosis of viral hepatitis in a single sample, but <50% could test for HBV/HDV. Alerts for continuity of care were available for HCV, but not HBV or HDV. POC device implementation is important for decentralized testing.

Indexed as

Hepatitis, Viral, HumanHepatitis BHepatitis CHepatitis DHospitalsHumansPoint-of-Care TestingSpainSurveys and Questionnaireshepatitis Bhepatitis Chepatitis Dintegrated diagnosispoint-of-care testing

Identifiers

PMID40431679
PMCPMC12116091

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.