Evidence map›Paper›PMID 40431612›Full record

ReviewViruses2025

Immunological Control of Herpes Simplex Virus Type 1 Infection: A Non-Thermal Plasma-Based Approach.

Julia Sutter, Jennifer L Hope, Brian Wigdahl, Vandana Miller, Fred C Krebs

Abstract readReview
In one paragraph

Review in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. HSV-1 as a Potential Driver of Alzheimer's Disease.Pathogens (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Julia SutterCenter for Molecular Virology and Gene Therapy, Institute for Molecular Medicine and Infectious Disease, and Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.ORCID 0009-0008-2533-736X
Jennifer L HopeCenter for Molecular Virology and Gene Therapy, Institute for Molecular Medicine and Infectious Disease, and Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.ORCID 0000-0002-2363-5442
Brian WigdahlCenter for Molecular Virology and Gene Therapy, Institute for Molecular Medicine and Infectious Disease, and Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.ORCID 0000-0002-5211-0936
Vandana MillerCenter for Molecular Virology and Gene Therapy, Institute for Molecular Medicine and Infectious Disease, and Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.ORCID 0000-0002-2323-2299
Fred C KrebsCenter for Molecular Virology and Gene Therapy, Institute for Molecular Medicine and Infectious Disease, and Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.ORCID 0000-0002-1530-4432

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herpes simplex virus type 1 (HSV-1) causes a lifelong infection due to latency established in the trigeminal ganglia, which is the source of recurrent outbreaks of cold sores. The lifelong persistence of HSV-1 is further facilitated by the lack of cure strategies, unsuccessful vaccine development, and the inability of the host immune system to clear HSV-1. Despite the inefficiencies of the immune system, the course of HSV-1 infection remains under strict immunological control. Specifically, HSV-1 is controlled by a CD8

Indexed as

Herpes SimplexHerpesvirus 1, HumanPlasma GasesAnimalsCD8-Positive T-LymphocytesHumansVirus LatencyPlasma GasesantiviralCD8+ T cellcold atmospheric plasmagas plasmaimmunotherapylatent infectionnon-thermal plasmareactivation

Identifiers

PMID40431612
PMCPMC12115788

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.