ArticleViruses2025
Stromal Interferon Regulatory Factor 3 Can Antagonize Human Papillomavirus Replication by Supporting Epithelial-to-Mesenchymal Transition.
Oluwamuyiwa T Amusan, Rebecca Lopez, Elijah Burks, Jessica Trammel, Gaurav Raikhy, Hongyan Guo, Jason Bodily
Abstract read
In one paragraphArticle in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Oluwamuyiwa T AmusanDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center-Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA.
Rebecca LopezDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center-Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA.
Elijah BurksDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center-Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA.ORCID 0009-0006-3423-8713 Jessica TrammelDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center-Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA.
Gaurav RaikhyDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center-Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA.
Hongyan GuoDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center-Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA.
Jason BodilyDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center-Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA.ORCID 0000-0001-9743-2085 Funding
Project 4-Tracking cytomegalovirus-primed long-lived NK cells in salivary glandP20GM134974 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ANDREW D YUROCHKO · 2021 to 2026
$15.0MCOBRE Center for Molecular and Tumor VirologyP30GM110703 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI SAPP, MARTIN · 2014 to 2018
$4.8MThThe Role of Epithelial-Stromal Communication in the Human Papillomavirus Type 16 Life CycleR01AI118904 · NIAID · LOUISIANA STATE UNIV HSC SHREVEPORT · PI BODILY, JASON M · 2015 to 2019
$1.6MBoosting Oncolytic HSV Immunotherapy by Enabling NecroptosisR21CA303392 · NCI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI GUO, HONGYAN · 2025 to 2025
$416kRole of receptor-interacting serine/threonine-protein kinase 3 (RIPK3) in Herpes Simplex Virus (HSV) EncephalitisR21AI175590 · NIAID · LOUISIANA STATE UNIV HSC SHREVEPORT · PI GUO, HONGYAN · 2023 to 2024
$402kFeist-Weiller Cancer CenterLSUHS Center for Emerging Viral ThreatsNCI NIH HHS R21 CA303392NIAID NIH HHS R01 AI118904NIAID NIH HHS R21 AI175590NIGMS NIH HHS P20 GM134974NIGMS NIH HHS P30 GM110703NIH HHS 1P20GM134974-21A1NIH HHS 1P30GM110703-21A1NIH HHS 1R01AI118904-15A1NIH HHS 1R21AI175590-24A1Science and Medicine Academic Research Training (SMART) program
6 · The paper itselfAbstract
Epithelia contribute to the innate immune system through barrier formation and through signaling to immune cells. When the barrier is breached, epithelial cells undergo epithelial-to-mesenchymal transition (EMT) as part of the wound healing process. EMT is largely directed by signals from the stromal microenvironment, including transforming growth factor beta (TGFβ1), and antagonizes normal epithelial differentiation. How EMT and innate immunity may be connected molecularly has not been explored, although both processes are likely to occur simultaneously. Keratinocytes are the host cell type for human papillomaviruses (HPV), which can induce EMT in certain conditions but also depend on differentiation for their replication. We previously found that the innate immune factor interferon regulatory factor 3 (IRF3) inhibits epithelial differentiation and reduces the expression of HPV16 late genes. Here we report that IRF3 in the stroma compartment promotes an EMT-like pattern of gene expression in an HPV16-containing epithelium. The depletion of stromal IRF3 resulted in the downregulation of TGFβ1-related signaling in both the stroma and epithelium. IRF3 binds to the
Indexed as
Epithelial-Mesenchymal TransitionHuman papillomavirus 16Interferon Regulatory Factor-3Papillomavirus InfectionsVirus ReplicationCell DifferentiationEpithelial CellsFibroblastsHuman Papillomavirus VirusesHumansImmunity, InnateKeratinocytesSignal TransductionStromal CellsTransforming Growth Factor beta1Interferon Regulatory Factor-3IRF3 protein, humanTransforming Growth Factor beta1epithelial-to-mesenchymal transition (EMT)human papillomavirus type 16 (HPV16)interferon regulatory factor 3 (IRF3)transforming growth factor beta 1 (TGFβ1)
Identifiers
PMID40431610
PMCPMC12115382
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