Evidence map›Paper›PMID 40431596›Full record

ArticleVeterinary sciences2025

Generation and Immunogenicity of Virus-like Particles Based on the Capsid Protein of a Chinese Epidemic Strain of Feline Panleukopenia Virus.

Erkai Feng, Guoliang Luo, Chunxia Wang, Wei Liu, Ruxun Yan, Xue Bai, Yuening Cheng

Abstract read
In one paragraph

Article in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Erkai FengKey Laboratory of Economic Animal Diseases, Ministry of Agriculture, Institute of Special Animal and Plant Science, Chinese Academy of Agriculture Science, Changchun 130111, China.
Guoliang LuoKey Laboratory of Economic Animal Diseases, Ministry of Agriculture, Institute of Special Animal and Plant Science, Chinese Academy of Agriculture Science, Changchun 130111, China.
Chunxia WangKey Laboratory of Economic Animal Diseases, Ministry of Agriculture, Institute of Special Animal and Plant Science, Chinese Academy of Agriculture Science, Changchun 130111, China.
Wei LiuChangchun Xinuo BioTechnology Co., Ltd., Changchun 130111, China.
Ruxun YanChangchun Xinuo BioTechnology Co., Ltd., Changchun 130111, China.
Xue BaiKey Laboratory of Economic Animal Diseases, Ministry of Agriculture, Institute of Special Animal and Plant Science, Chinese Academy of Agriculture Science, Changchun 130111, China.
Yuening ChengKey Laboratory of Economic Animal Diseases, Ministry of Agriculture, Institute of Special Animal and Plant Science, Chinese Academy of Agriculture Science, Changchun 130111, China.

Funding

National Key Research and Development Program of China 2023YFD1800700
6 · The paper itself

Abstract

Feline panleukopenia (FPL), caused by the feline panleukopenia virus (FPLV), is a severe and highly contagious viral disease with high morbidity and mortality. Vaccination remains the gold standard for preventing and controlling this debilitating condition. The viral protein VP2 serves as the major immunogen of FPLV and represents the key target antigen in the development of a novel FPLV vaccine. Virus-like particle (VLP)-based vaccines have emerged as next-generation vaccine candidates due to their high immunogenicity and safe profile. In this study, a baculovirus expression vector system (BEVS) was employed to generate FPLV-VLPs through recombinant expression of the VP2 protein of a Chinese epidemic strain (Ala91Ser, Ile101Thr) of FPLV. The resulting FPLV-VLPs demonstrated markedly enhanced antigenicity and hemagglutination activity, achieving a hemagglutination titer of up to 1:2

Indexed as

baculovirus expressionfeline panleukopeniafeline panleukopenia virusvaccinevirus-like particles

Identifiers

PMID40431596
PMCPMC12116079

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.