Evidence map›Paper›PMID 40431589›Full record

ArticleVeterinary sciences2025

Differential Expression of LHR and FSHR in Canine Mammary Tumors: Correlation with Malignancy and Spay Status.

Yujue Li, Siying Wang, Jiaxuan Gao, Xuerou Tu, Shihui Yu, Yang Liu, Zhaoxia Zhang, Yuan Cui, Yougang Zhong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yujue LiDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Siying WangClinical Laboratory Diagnostic Center, China Agricultural University Veterinary Teaching Hospital, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Jiaxuan GaoDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Xuerou TuDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Shihui YuClinical Laboratory Diagnostic Center, China Agricultural University Veterinary Teaching Hospital, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Yang LiuClinical Laboratory Diagnostic Center, China Agricultural University Veterinary Teaching Hospital, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Zhaoxia ZhangClinical Laboratory Diagnostic Center, China Agricultural University Veterinary Teaching Hospital, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Yuan CuiClinical Laboratory Diagnostic Center, China Agricultural University Veterinary Teaching Hospital, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Yougang ZhongDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.

Funding

National Key Research and Development Program of China 2023YFD180110
6 · The paper itself

Abstract

Canine mammary tumors (CMTs) constitute one of the most prevalent malignancies in female canines, whereas the functional involvement of gonadotropin receptors-luteinizing hormone receptor (LHR) and follicle-stimulating hormone receptor (FSHR)-in these neoplasms remains uncharacterized. This study investigated LHR and FSHR expression in 79 CMTs and 14 normal mammary tissues collected from 59 female dogs (ethical approval AW82903202-2-3), using immunohistochemistry (IHC) and quantitative real-time PCR, specifically examining their association with tumor malignancy and spay status. Relative to normal mammary tissue, CMTs exhibited statistically significant downregulation of both LHR and FSHR transcripts and corresponding proteins (

Indexed as

canine mammary tumorsfollicle-stimulating hormone receptorluteinizing hormone receptorspay statustumor malignancy

Identifiers

PMID40431589
PMCPMC12116059

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.