Evidence map›Paper›PMID 40431403›Full record

ArticleNutrients2025

Dietary Micronutrient Intake in Long-Term Survivors of Pediatric Hematopoietic Stem Cell Transplantation.

Louise Lindkvist Pedersen, Maria Ebbesen Sørum, Anne Nissen, Tina Gerbek, Karin Kok, Kaspar Sørensen, Martin Kaj Fridh, Christian Mølgaard, Klaus Gottlob Müller

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Observational
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Louise Lindkvist PedersenDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.ORCID 0009-0007-7086-7805
Maria Ebbesen SørumDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.ORCID 0000-0002-3907-7916
Anne NissenDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.ORCID 0000-0001-9790-7642
Tina GerbekDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
Karin KokDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
Kaspar SørensenDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
Martin Kaj FridhDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.ORCID 0000-0002-1560-0530
Christian MølgaardPediatric Nutrition Unit, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.ORCID 0000-0002-5311-9457
Klaus Gottlob MüllerDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.ORCID 0000-0002-5278-1983

Funding

Danish Childhood Cancer Foundation 2019-5990 & 2020-6764
6 · The paper itself

Abstract

backgroundSurvivors of hematopoietic stem cell transplantation (HSCT) during childhood face significant late effects. This study aimed to map the dietary micronutrient intake of long-term survivors of pediatric HSCT and explore its associations with transplant outcomes, body composition, and physical capacity.

methodsWe included 85 long-term survivors of HSCT (median age 30 years) The median time since HSCT was 19.9 years, reflecting a long-term survivor population. Dietary intake was assessed using a 3-day food record. Body composition was measured by DXA, and physical capacity was evaluated through cardiorespiratory fitness and physical performance tests.

resultsWe observed an inadequate intake of several vitamins and minerals including vitamins A, C, D, E, selenium, and potassium, with a median intake below recommendations. While dietary intake of vitamin D was reduced in patients with chronic graft versus host disease (cGvHD), the occurrence of cGvHD was not associated with overall micronutrient intake. Twelve percent of the participants had reduced skeletal muscle mass and 16% displayed a low bone mass density during DXA scans. These conditions were not related to the micronutrient intake. Likewise, reduced cardiorespiratory fitness and physical performance were unrelated to micronutrient intake. Total energy intake was found to significantly influence micronutrient intake (

conclusionsLong-term survivors of pediatric HSCT demonstrated inadequate intake of multiple micronutrients. These findings suggest that inclusion of comprehensive micronutrient assessment and nutritional guidance should be considered for inclusion in follow-up care protocols.

Indexed as

DietHematopoietic Stem Cell TransplantationMicronutrientsSurvivorsAdolescentAdultBody CompositionBone DensityCardiorespiratory FitnessChildChild, PreschoolFemaleGraft vs Host DiseaseHumansMaleNutritional StatusMicronutrientsbody compositionlate effectsmicronutrientsnutritionpediatric hematopoietic stem cell transplantationphysical performance

Identifiers

PMID40431403
PMCPMC12113892

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.