Evidence map›Paper›PMID 40431311›Full record

ArticleMicroorganisms2025

Irritable Bowel Syndrome with Diarrhea (IBS-D): Effects of

Francesco Di Pierro, Fabrizio Ficuccilli, Laura Tessieri, Francesca Menasci, Chiara Pasquale, Amjad Khan, Fazle Rabbani, Nazia Mumtaz Memon, Massimiliano Cazzaniga, Alexander Bertuccioli and 6 more

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Irritable bowel syndrome with diarrhea: time to change practice?Current opinion in gastroenterology · 2026
    Review
  5. Article
  6. Review
  7. Recent advances in the positive role ofFrontiers in immunology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Francesco Di PierroMicrobiota International Clinical Society, 10123 Turin, Italy.ORCID 0000-0001-6654-8675
Fabrizio FicuccilliNursing Home Quisisana, 00197 Rome, Italy.
Laura TessieriNursing Home Quisisana, 00197 Rome, Italy.
Francesca MenasciNursing Home Quisisana, 00197 Rome, Italy.
Chiara PasqualeNursing Home Quisisana, 00197 Rome, Italy.
Amjad KhanDepartment of Biochemistry, Liaquat University of Medical & Health Sciences (LUMHS), Jamshoro 76090, Pakistan.
Fazle RabbaniDepartment of Psychiatry, Lady Reading Hospital (LRH), Peshawar 25000, Pakistan.
Nazia Mumtaz MemonDepartment of Pathology, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro 76090, Pakistan.
Massimiliano CazzanigaScientific & Research Department, Velleja Research, 20125 Milan, Italy.
Alexander BertuccioliDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy.ORCID 0000-0002-3922-9115
Mariarosaria MateraDepartment of Pediatric Emergencies, Misericordia Hospital, 58100 Grosseto, Italy.ORCID 0009-0008-2115-1701
Ilaria CavecchiaMicrobiota International Clinical Society, 10123 Turin, Italy.ORCID 0009-0007-2326-2328
Martino RecchiaUnit of Clinical Epidemiology and Biostatistics, Mario Negri Institute Alumni Association (MNIAA), 20156 Milan, Italy.
Chiara Maria PalazziMicrobiota International Clinical Society, 10123 Turin, Italy.
Maria Laura TandaEndocrine Unit, Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.ORCID 0000-0001-7551-1751
Nicola ZerbinatiDepartment of Medicine and Technological Innovation, University of Insubria, 21100 Varese, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a functional gastrointestinal disorder characterized by altered motility, abdominal pain, and dysbiosis-particularly reduced biodiversity and a lower abundance of butyrate-producing bacteria. Strategies that modulate the gut microbiota may offer therapeutic benefit.

Indexed as

butyrate producersClostridium butyricum CBM588IBS-Dirritable bowel syndrome

Identifiers

PMID40431311
PMCPMC12113862

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.