Evidence map›Paper›PMID 40431266›Full record

ArticleMicroorganisms2025

Reducing Functional Domain of Histatin 5 Improves Antifungal Activity and Prevents Proteolytic Degradation.

Carolina R Zambom, Gabriel Bernardes, Fauller Henrique da Fonseca, Gabriela Vieira Silva Zolin, Mariana de Melo Faceto Portella, Lina Maria Marin, Edson Crusca, Ed S Krol, Walter L Siqueira, Saulo Santesso Garrido

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carolina R ZambomInstitute of Chemistry, Department of Biochemistry and Organic Chemistry, UNESP-Sao Paulo State University, Araraquara 14800-060, Brazil.
Gabriel BernardesCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.ORCID 0000-0002-2249-9856
Fauller Henrique da FonsecaInstitute of Chemistry, Department of Biochemistry and Organic Chemistry, UNESP-Sao Paulo State University, Araraquara 14800-060, Brazil.ORCID 0000-0002-2107-1321
Gabriela Vieira Silva ZolinInstitute of Chemistry, Department of Biochemistry and Organic Chemistry, UNESP-Sao Paulo State University, Araraquara 14800-060, Brazil.ORCID 0000-0002-3194-945X
Mariana de Melo Faceto PortellaInstitute of Chemistry, Department of Biochemistry and Organic Chemistry, UNESP-Sao Paulo State University, Araraquara 14800-060, Brazil.ORCID 0000-0003-4521-7863
Lina Maria MarinCollege of Dentistry, University of Saskatchewan, Saskatoon, SK S7N 5E4, Canada.ORCID 0000-0003-2108-4656
Edson CruscaInstitute of Chemistry, Department of Biochemistry and Organic Chemistry, UNESP-Sao Paulo State University, Araraquara 14800-060, Brazil.ORCID 0000-0002-7519-049X
Ed S KrolCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.ORCID 0000-0002-2957-6236
Walter L SiqueiraCollege of Dentistry, University of Saskatchewan, Saskatoon, SK S7N 5E4, Canada.ORCID 0000-0003-1921-3658
Saulo Santesso GarridoInstitute of Chemistry, Department of Biochemistry and Organic Chemistry, UNESP-Sao Paulo State University, Araraquara 14800-060, Brazil.ORCID 0000-0001-7122-1132

Funding

Canada Foundation for Innovation 25116CIHR 106657CIHR 400347Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/03018-1
6 · The paper itself

Abstract

Histatin 5 (Hst5) is an antifungal peptide (AFP) naturally produced by parotid glands with strong activity against

Indexed as

antifungal peptidesdegradationhistatin 5P-113peptidesproteolysissalivaSPPS

Identifiers

PMID40431266
PMCPMC12113730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.