Evidence map›Paper›PMID 40431119›Full record

ArticlePlants (Basel, Switzerland)2025

The Alkaloid Gelsemine Reduces Aβ Peptide Toxicity by Targeting Transglutaminase Type 2 Enzyme.

Jessica Panes-Fernández, Ana M Marileo, Nicole Espinoza-Rubilar, Macarena E Meza, Bernardita A Salgado-Martínez, Krishna Gaete-Riquelme, Gustavo Moraga-Cid, Patricio A Castro, Carlos F Burgos, Jorge Fuentealba and 1 more

Abstract read
In one paragraph

Article in Plants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jessica Panes-FernándezLaboratorio de Screening de Compuestos Neuroactivos, Departamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070409, Chile.ORCID 0000-0002-5501-6582
Ana M MarileoLaboratorio de Neurofarmacología, Departamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070409, Chile.ORCID 0000-0002-6301-3242
Nicole Espinoza-RubilarLaboratorio de Screening de Compuestos Neuroactivos, Departamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070409, Chile.
Macarena E MezaLaboratorio de Screening de Compuestos Neuroactivos, Departamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070409, Chile.
Bernardita A Salgado-MartínezLaboratorio de Neurofarmacología, Departamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070409, Chile.
Krishna Gaete-RiquelmeLaboratorio de Neurofarmacología, Departamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070409, Chile.
Gustavo Moraga-CidDepartamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070409, Chile.ORCID 0000-0002-0260-8744
Patricio A CastroDepartamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070409, Chile.ORCID 0000-0002-8131-3265
Carlos F BurgosDepartamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070409, Chile.ORCID 0000-0001-6738-8589
Jorge FuentealbaLaboratorio de Screening de Compuestos Neuroactivos, Departamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070409, Chile.
Gonzalo E YévenesLaboratorio de Neurofarmacología, Departamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070409, Chile.

Funding

Agencia Nacional de Investigación y Desarrollo FONDECYT 11221211Agencia Nacional de Investigación y Desarrollo FONDECYT 1211082Agencia Nacional de Investigación y Desarrollo FONDECYT 1231038Agencia Nacional de Investigación y Desarrollo FONDECYT 1250856Agencia Nacional de Investigación y Desarrollo FONDECYT 1251488
6 · The paper itself

Abstract

Gelsemine, a naturally occurring indole alkaloid derived from plants of the

Indexed as

Alzheimer’s disease (AD)gelseminenatural alkaloidneuronal activitytransglutaminase type 2 (TG2)β-amyloid peptide (Aβ peptide)

Identifiers

PMID40431119
PMCPMC12114793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.