Evidence map›Paper›PMID 40430946›Full record

ArticlePharmaceutics2025

Newborn Intravenous Injection of Liposomal CRISPR/Cas9 Complex Has No Incidence of Off-Targets or Tumors in Mice.

Vinícius Monteagudo, Larissa Cristina Barbosa Flores, Melaine Lopes, Flavia Nathiely Silveira Fachel, Giselle Martins, Marina Siebert, Willian da Silva Carniel, Tuane Nerissa Alves Garcez, Helder Ferreira Teixeira, Ursula Matte and 4 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Overview of Delivery Methods for Gene Editing.Methods in molecular biology (Clifton, N.J.) · 2027
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Vinícius MonteagudoGraduate Program in Pharmaceutical Sciences, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752/lab 606, Porto Alegre 90610-000, RS, Brazil.ORCID 0009-0009-7361-1770
Larissa Cristina Barbosa FloresGraduate Program in Pharmaceutical Sciences, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752/lab 606, Porto Alegre 90610-000, RS, Brazil.
Melaine LopesGraduate Program in Pharmaceutical Sciences, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752/lab 606, Porto Alegre 90610-000, RS, Brazil.
Flavia Nathiely Silveira FachelGraduate Program in Pharmaceutical Sciences, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752/lab 606, Porto Alegre 90610-000, RS, Brazil.ORCID 0000-0002-0777-9497
Giselle MartinsGraduate Program in Pharmaceutical Sciences, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752/lab 606, Porto Alegre 90610-000, RS, Brazil.
Marina SiebertCells, Tissues, and Genes Research Group, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.
Willian da Silva CarnielGraduate Program in Pharmaceutical Sciences, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752/lab 606, Porto Alegre 90610-000, RS, Brazil.ORCID 0009-0001-2820-2814
Tuane Nerissa Alves GarcezCells, Tissues, and Genes Research Group, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.
Helder Ferreira TeixeiraGraduate Program in Pharmaceutical Sciences, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752/lab 606, Porto Alegre 90610-000, RS, Brazil.
Ursula MatteCells, Tissues, and Genes Research Group, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.ORCID 0000-0003-4977-6662
Roberto GiuglianiCells, Tissues, and Genes Research Group, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.
Guilherme BaldoCells, Tissues, and Genes Research Group, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.
Édina PolettoDepartment of Pediatrics, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-0554-0295
Roselena Silvestri SchuhGraduate Program in Pharmaceutical Sciences, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752/lab 606, Porto Alegre 90610-000, RS, Brazil.ORCID 0000-0003-4189-0436

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brazil (CAPES) Finance Code 001FIPE/HCPA 20160482National Council for Scientific and Technological Development (CNPq) 470888/2014-8, 403587/2021-2, and 141742/2014-3
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CRISPR/Cas9gene editingliposomeoff-targettumor

Identifiers

PMID40430946
PMCPMC12114706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.