Evidence map›Paper›PMID 40430919›Full record

ArticlePharmaceutics2025

Evaluation of the PP6D5 Polymer as a Novel Non-Viral Vector in the Development of a CRISPR/nCas9-Based Gene Therapy for Tay-Sachs Disease.

Jacky M Guerrero-Vargas, Diego A Suarez-Garcia, Andrés F Leal, Ivonne L Diaz-Ariza, León D Pérez-Pérez, Angela J Espejo-Mojica, Carlos J Alméciga-Díaz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jacky M Guerrero-VargasInstitute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá D.C. 110231, Colombia.
Diego A Suarez-GarciaInstitute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá D.C. 110231, Colombia.ORCID 0000-0001-9519-4706
Andrés F LealInstitute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá D.C. 110231, Colombia.ORCID 0000-0001-5956-1986
Ivonne L Diaz-ArizaDepartment of Chemistry, Universidad Nacional de Colombia, Bogotá D.C. 11001, Colombia.ORCID 0000-0003-4801-2791
León D Pérez-PérezDepartment of Chemistry, Universidad Nacional de Colombia, Bogotá D.C. 11001, Colombia.ORCID 0000-0001-7473-7855
Angela J Espejo-MojicaInstitute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá D.C. 110231, Colombia.ORCID 0000-0001-9670-6435
Carlos J Alméciga-DíazInstitute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá D.C. 110231, Colombia.ORCID 0000-0001-6484-1173

Funding

Pontificia Universidad Javeriana Activity 120289301011ZZPontificia Universidad Javeriana InvestigarPUJ 20567Pontificia Universidad Javeriana InvestigarPUJ 20646
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

amphiphilic graft copolymerCRISPR/nCas9gene therapynon-viral vectorsTay–Sachs diseaseβ-hexosaminidase A

Identifiers

PMID40430919
PMCPMC12115165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.