Evidence map›Paper›PMID 40430868›Full record

ReviewPharmaceutics2025

Nanochitin and Nanochitosan in Pharmaceutical Applications: Innovations, Applications, and Future Perspective.

José Roberto Vega-Baudrit, Mary Lopretti, Gabriela Montes de Oca, Melissa Camacho, Diego Batista, Yendry Corrales, Andrea Araya, Badr Bahloul, Yohann Corvis, Luis Castillo-Henríquez

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

José Roberto Vega-BaudritLanotec Cenat Conare, San José 10101, Costa Rica.ORCID 0000-0002-2002-1744
Mary LoprettiLaboratorio de Técnicas Nucleares Aplicadas a la Bioquímica y Biotecnología, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Montevideo 10129, Uruguay.
Gabriela Montes de OcaCEDS, Universidad Técnica Nacional UTN, Alajuela 20101, Costa Rica.ORCID 0000-0003-2012-816X
Melissa CamachoCEDS, Universidad Técnica Nacional UTN, Alajuela 20101, Costa Rica.
Diego BatistaLanotec Cenat Conare, San José 10101, Costa Rica.
Yendry CorralesLanotec Cenat Conare, San José 10101, Costa Rica.
Andrea ArayaLanotec Cenat Conare, San José 10101, Costa Rica.ORCID 0000-0001-9809-6079
Badr BahloulDrug Development Laboratory LR12ES09, Faculty of Pharmacy, Monastir University, Monastir 5060, Tunisia.ORCID 0000-0001-7512-1331
Yohann CorvisChemical and Biological Technologies for Health Group (UTCBS), Universite Paris Cite, 75023 Paris, France.ORCID 0000-0002-4865-3348
Luis Castillo-HenríquezLanotec Cenat Conare, San José 10101, Costa Rica.ORCID 0000-0001-5276-4772

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanochitin is a nanoscale form of chitin-a polysaccharide found in the exoskeletons of crustaceans, insects, and some fungal cell walls-that is newly garnering significant attention in the pharmaceutical space. Its good properties, such as biocompatibility, biodegradability, and an easily adjustable surface, render it attractive for various medical and pharmaceutical applications. Nanochitin, from drug delivery systems and wound-care formulations to vaccine adjuvants and antimicrobial strategies, has demonstrated its strong potential in meeting diverse therapeutic needs. This review covers the background of nanochitin, including methods for its extraction and refining and its principal physicochemical and biological properties. It further discusses various hydrolysis and enzymatic approaches for the structural and functional characterization of nanochitin and highlights some pharmaceutical applications where this biopolymer has been studied. The review also addresses toxicity issues, regulatory matters, and challenges in large-scale industrial production. Finally, it underscores novel avenues of investigation and future opportunities, emphasizing the urgent requirement for standardized production methods, rigorous safety assessment, and interdisciplinary partnerships to maximize nanochitin's potential in pharmaceutical research, demonstrating the importance of chitin in drug delivery.

Indexed as

biocompatibilitychitinchitosandrug deliverynanochitinnanochitosantherapeutic needs

Identifiers

PMID40430868
PMCPMC12114985

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.