Evidence map›Paper›PMID 40430844›Full record

ReviewPharmaceutics2025

Use of Computational Intelligence in Customizing Drug Release from 3D-Printed Products: A Comprehensive Review.

Fantahun Molla Kassa, Souha H Youssef, Yunmei Song, Sanjay Garg

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fantahun Molla KassaCentre for Pharmaceutical Innovation (CPI), Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.ORCID 0000-0002-4556-1245
Souha H YoussefCentre for Pharmaceutical Innovation (CPI), Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
Yunmei SongCentre for Pharmaceutical Innovation (CPI), Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.ORCID 0000-0003-0008-5895
Sanjay GargCentre for Pharmaceutical Innovation (CPI), Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.ORCID 0000-0001-7253-2629

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Computational intelligence (CI) mimics human intelligence by expanding the capabilities of machines in data analysis, pattern recognition, and making informed decisions. CI has shown promising contributions to advancements in drug discovery, formulation, and manufacturing. Its ability to analyze vast amounts of patient data and optimize drug formulations by predicting pharmacokinetic and pharmacodynamic responses makes it a very useful platform for personalized medicine. The integration of CI with 3D printing further strengthens this potential, as 3D printing enables the fabrication of personalized medicines with precise doses, controlled-release profiles, and complex formulations. Furthermore, the automated and digital capabilities of 3D printing make it suitable for integration with CI. CI has proven useful in predicting material printability, optimizing drug release rates, designing complex structures, ensuring quality control, and improving manufacturing processes in 3D printing. In the context of customizing drug release from 3D-printed products, CI techniques have been applied to predict drug release from input variables and to design geometries that achieve the desired release profile. This review explores the role of CI in customizing drug release from 3D-printed formulations. It provides overview of limitations of 3D printing; how CI can overcome these challenges, and its potential in customizing drug release; a comparison of CI with other methods of optimization; and real-world examples of CI integration in 3D printing.

Indexed as

3D printingCICI-driven drug releasecomputational intelligencecustomizing drug releasepersonalized medicinethree-dimensional printing

Identifiers

PMID40430844
PMCPMC12114986

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.