Evidence map›Paper›PMID 40430842›Full record

ArticlePharmaceutics2025

Drug Combinations Targeting FAK and MEK Overcomes Tumor Heterogeneity in Glioblastoma.

Muhammad Furqan, Richard J R Elliott, Peter W K Nagle, John C Dawson, Roza Masalmeh, Virginia Alvarez Garcia, Alison F Munro, Camilla Drake, Gillian M Morrison, Steven M Pollard and 4 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Muhammad FurqanEdinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.
Richard J R ElliottEdinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.ORCID 0009-0002-0174-5488
Peter W K NagleEdinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.ORCID 0000-0001-6150-2571
John C DawsonEdinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.ORCID 0000-0001-5713-1026
Roza MasalmehEdinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.
Virginia Alvarez GarciaEdinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.
Alison F MunroEdinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.ORCID 0000-0001-5345-5816
Camilla DrakeEdinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.ORCID 0009-0003-0089-2571
Gillian M MorrisonCancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.
Steven M PollardCancer Research UK Scotland Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.
Daniel EbnerNuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford OX3 7BN, UK.ORCID 0000-0002-6495-7026
Valerie G BruntonEdinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.ORCID 0000-0002-7778-8794
Margaret C FrameEdinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.
Neil O CarragherEdinburgh Cancer Research, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.ORCID 0000-0001-5541-9747

Funding

Brain Tumour Charity GN-000676Cancer Research UK A21922Cancer Research UK C42454/A28596
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

chemogenomic screeningcombination therapyfocal adhesion kinase (FAK)glioblastomaMEKtumor heterogeneity

Identifiers

PMID40430842
PMCPMC12114623

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.