Evidence map›Paper›PMID 40430815›Full record

ArticlePathogens (Basel, Switzerland)2025

Bacterial Acute Otitis Media Complicated with Otorrhea in a Children's Hospital in the Era of Pneumococcal Conjugate Vaccines.

Irene Tzovara, Anastasios Doudoulakakis, Georgios Kalogeras, Emmanouil Koutouzis, Charilaos Dellis, Sophia Pasparakis, Marietta Charakida, Evangelia Lebessi, Elisavet Bozavoutoglou, Michael Tsakanikos and 2 more

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Irene TzovaraFirst Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital, 11527 Athens, Greece.ORCID 0000-0001-6503-4226
Anastasios DoudoulakakisDepartment of Microbiology, "P. & A. Kyriakou" Children's Hospital, 11527 Athens, Greece.ORCID 0000-0002-5286-5896
Georgios KalogerasDepartment of Microbiology, "P. & A. Kyriakou" Children's Hospital, 11527 Athens, Greece.
Emmanouil KoutouzisInfectious Diseases and Chemotherapy Research Laboratory, First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital, 11527 Athens, Greece.
Charilaos DellisInfectious Diseases and Chemotherapy Research Laboratory, First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital, 11527 Athens, Greece.
Sophia PasparakisSecond Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, "P. & A. Kyriakou" Children's Hospital, 11527 Athens, Greece.
Marietta CharakidaSecond Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, "P. & A. Kyriakou" Children's Hospital, 11527 Athens, Greece.
Evangelia LebessiDepartment of Microbiology, "P. & A. Kyriakou" Children's Hospital, 11527 Athens, Greece.ORCID 0000-0002-2069-9416
Elisavet BozavoutoglouDepartment of Microbiology, "P. & A. Kyriakou" Children's Hospital, 11527 Athens, Greece.
Michael TsakanikosEar Nose and Throat Department, "P. & A. Kyriakou" Children's Hospital, 11527 Athens, Greece.
Vassiliki SyriopoulouInfectious Diseases and Chemotherapy Research Laboratory, First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital, 11527 Athens, Greece.ORCID 0000-0003-0592-9591
Maria TsoliaSecond Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, "P. & A. Kyriakou" Children's Hospital, 11527 Athens, Greece.ORCID 0000-0003-2485-4409

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute otitis media (AOM) is a common disease among children and can be complicated by otorrhea (AOMO). In 2010, the 13-valent Pneumococcal Conjugate Vaccine (PCV13) replaced the 7-valent vaccine (PCV7) in Greece. We aimed to describe the microbiological profile of bacterial ΑOMO among children younger than 16 years across the two PCV periods in a tertiary children's hospital. Middle ear fluid cultures from 2418 children with AOMO were collected from 2007 to 2022. Otopathogens were isolated and tested for antimicrobial susceptibility. Data were compared between the PCV7- (2007-2011) and PCV13-period (2012-2019). The most common otopathogen over the 16-year period was

Indexed as

Otitis MediaOtitis Media with EffusionPneumococcal VaccinesAcute DiseaseAdolescentAnti-Bacterial AgentsChildChild, PreschoolDrug Resistance, BacterialFemaleGreeceHaemophilus influenzaeHeptavalent Pneumococcal Conjugate VaccineHospitals, PediatricHumansInfant13-valent pneumococcal vaccineAnti-Bacterial AgentsHeptavalent Pneumococcal Conjugate VaccinePneumococcal VaccinesVaccines, Conjugateacute otitis mediaantibiotic resistanceotorrheapneumococcal conjugate vaccinepneumococcal serotypessurveillance

Identifiers

PMID40430815
PMCPMC12114500

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.