Evidence map›Paper›PMID 40430572›Full record

ArticlePharmaceuticals (Basel, Switzerland)2025

Design, Synthesis, and Evaluation of Antinociceptive Properties of Novel CBD-Based Terpene-Cinnamoyl-Acyl-Hydrazone Analogues.

Mikaela Lucinda de Souza, João Pedro Barros de Paiva, Graziella Dos Reis Rosa Franco, Vanessa Silva Gontijo, Marina Amaral Alves, Hygor Marcos Ribeiro de Souza, Anna Carolina Pereira Lontra, Eduardo Araújo de Oliveira, Thaís Biondino Sardella Giorno, Isabella Alvim Guedes and 3 more

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mikaela Lucinda de SouzaPeQuiM-Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas, Alfenas 37133-840, MG, Brazil.ORCID 0000-0002-2723-6385
João Pedro Barros de PaivaLaboratory of Pharmacology of Pain and Inflammation, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-577, RJ, Brazil.
Graziella Dos Reis Rosa FrancoPeQuiM-Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas, Alfenas 37133-840, MG, Brazil.
Vanessa Silva GontijoPeQuiM-Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas, Alfenas 37133-840, MG, Brazil.ORCID 0000-0003-1674-818X
Marina Amaral AlvesLaboratory of Metabolomics-LabMeta/LADETEC, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro 21941-598, RJ, Brazil.
Hygor Marcos Ribeiro de SouzaLaboratory of Metabolomics-LabMeta/LADETEC, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro 21941-598, RJ, Brazil.ORCID 0009-0005-1358-1689
Anna Carolina Pereira LontraLaboratory of Pharmacology of Pain and Inflammation, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-577, RJ, Brazil.
Eduardo Araújo de OliveiraLaboratory of Pharmacology of Pain and Inflammation, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-577, RJ, Brazil.
Thaís Biondino Sardella GiornoLaboratory of Pharmacology of Pain and Inflammation, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-577, RJ, Brazil.
Isabella Alvim GuedesNational Laboratory for Scientific Computing, Molecular Modeling in Biological Systems Group, Petrópolis 25651-075, RJ, Brazil.
Laurent Emmanuel DardenneNational Laboratory for Scientific Computing, Molecular Modeling in Biological Systems Group, Petrópolis 25651-075, RJ, Brazil.ORCID 0000-0001-8518-8062
Patrícia Dias FernandesLaboratory of Pharmacology of Pain and Inflammation, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-577, RJ, Brazil.ORCID 0000-0001-6870-6745
Claudio ViegasPeQuiM-Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas, Alfenas 37133-840, MG, Brazil.ORCID 0000-0002-7799-992X

Funding

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro FAPERJ, # SEI-260003/003464/2022; SEI-260003/001154/2023Fundação de Amparo à Pesquisa do Estado de Minas Gerais FAPEMIG, #APQ-CEX00518-17National Council for Scientific and Technological Development CNPq, #406739-2018-8, # 308557/2021-2; #306900/2023-8National Institute of Science and Technology of Drugs and Medicines INCT-INOFAR, #465249/2014-0, #402176/2024-3
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

acute painantinociceptive activitybioactive acyl-hydrazone derivativescannabidiol-based analoguesCBD analogues

Identifiers

PMID40430572
PMCPMC12114903

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.