Evidence map›Paper›PMID 40430422›Full record

ArticleMolecules (Basel, Switzerland)2025

Immunotoxicity Study of Cucurbit[n]urils (n = 6, 7, 8) and Modeling of Interaction with Some Monocyte Receptors by a Molecular Docking Method.

Saule B Zhautikova, Nursipat N Abdykhanova, Dmitry A Fedorishin, Yelena G Shapovalova, Andrei I Khlebnikov, Abdigali A Bakibaev, Irina A Kurzina, Saule K Kabieva, Nazerke Boranbay, Gaziza M Zhumanazarova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saule B ZhautikovaKaraganda Medical University, Karaganda 100900, Kazakhstan.
Nursipat N AbdykhanovaKaraganda Industrial University, Temirtau 101400, Kazakhstan.
Dmitry A FedorishinDepartment of Natural Compounds, Chemical Faculty, Pharmaceutical and Medical Chemistry, National Research Tomsk State University, Tomsk 634050, Russia.ORCID 0000-0001-9492-536X
Yelena G ShapovalovaDepartment of Natural Compounds, Chemical Faculty, Pharmaceutical and Medical Chemistry, National Research Tomsk State University, Tomsk 634050, Russia.
Andrei I KhlebnikovDepartment of Natural Compounds, Chemical Faculty, Pharmaceutical and Medical Chemistry, National Research Tomsk State University, Tomsk 634050, Russia.ORCID 0000-0002-3022-4510
Abdigali A BakibaevDepartment of Natural Compounds, Chemical Faculty, Pharmaceutical and Medical Chemistry, National Research Tomsk State University, Tomsk 634050, Russia.ORCID 0000-0002-3335-3166
Irina A KurzinaDepartment of Natural Compounds, Chemical Faculty, Pharmaceutical and Medical Chemistry, National Research Tomsk State University, Tomsk 634050, Russia.ORCID 0000-0003-4976-2295
Saule K KabievaKaraganda Industrial University, Temirtau 101400, Kazakhstan.
Nazerke BoranbayKaraganda Industrial University, Temirtau 101400, Kazakhstan.
Gaziza M ZhumanazarovaKaraganda Industrial University, Temirtau 101400, Kazakhstan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, cucurbit[n]urils (n = 6, 7, 8) were carefully evaluated for their cytotoxicity and immunotoxicity to human peripheral blood monocytes. The cytotoxicity was studied by evaluating the survival of monocytes, while the immunotoxicity level was assessed by analyzing the inflammatory mediators secreted by them using an enzyme-linked immunosorbent assay. It was found that cucurbit[n]urils (n = 6, 7, 8) in the used concentration (10

Indexed as

ImidazolesMolecular Docking SimulationMonocytesCell SurvivalCucurbit(n)urilsCytokinesHeterocyclic Compounds, 2-RingHumansImidazolidinesMacrocyclic CompoundsMacrophagesToll-Like ReceptorsCucurbit(n)urilsCytokinesHeterocyclic Compounds, 2-RingImidazolesImidazolidinesMacrocyclic CompoundsToll-Like Receptorscucurbit[6]urilcucurbit[7]urilcucurbit[8]urilcytotoxicityimmunotoxicitymolecular dockingmonocytesToll-like receptors

Identifiers

PMID40430422
PMCPMC12114219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.