Evidence map›Paper›PMID 40430418›Full record

ArticleMolecules (Basel, Switzerland)2025

A Natural Inhibitor, 1'

Kkotnara Park, Isoo Youn, Jung Min Suh, Min Hye Choi, Da-Woon Bae, Soo-Bong Park, Mi Hee Kwack, Sun-Shin Cha, Dae Sik Jang, Young Kwan Sung and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kkotnara ParkDepartment of Life Sciences, Ewha Womans University, Seoul 03760, Republic of Korea.
Isoo YounCollege of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea.
Jung Min SuhDepartment of Life Sciences, Ewha Womans University, Seoul 03760, Republic of Korea.ORCID 0009-0006-9853-1935
Min Hye ChoiDepartment of Life Sciences, Ewha Womans University, Seoul 03760, Republic of Korea.
Da-Woon BaeDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.ORCID 0000-0002-2632-6565
Soo-Bong ParkDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.ORCID 0000-0002-1426-8230
Mi Hee KwackDepartment of Immunology, School of Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.ORCID 0000-0002-7381-6532
Sun-Shin ChaDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.
Dae Sik JangDepartment of Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0000-0001-5472-5232
Young Kwan SungDepartment of Immunology, School of Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.ORCID 0000-0002-5122-4616
Yun Soo BaeDepartment of Life Sciences, Ewha Womans University, Seoul 03760, Republic of Korea.ORCID 0000-0002-9944-3180
Eun Kyoung SeoCollege of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea.ORCID 0000-0002-1950-2348

Funding

National Cancer Center NCC-2211720National Research Foundation of Korea 2021R1A2C1003350National Research Foundation of Korea 2022R1A2C3006924
6 · The paper itself

Abstract

Androgenetic alopecia is associated with testosterone-mediated anagen-to-catagen transition and matrix keratinocyte apoptosis in hair follicle cells. Activation of Nox isozymes is involved in testosterone-mediated keratinocyte apoptosis, leading to androgenetic alopecia. This indicates that Nox isozymes can serve as therapeutic targets for androgenetic alopecia. The isolated compounds from natural products were screened to evaluate their ROS-inhibition efficacy and it was found that 1'

Indexed as

AlopeciaBenzyl AlcoholsBiological ProductsEnzyme InhibitorsNADPH OxidasesTestosteroneAlpiniaAnimalsApoptosisDisease Models, AnimalHair FollicleHumansHydrogen PeroxideKeratinocytesMaleMice1'-acetoxychavicol acetateBenzyl AlcoholsBiological ProductsEnzyme InhibitorsHydrogen PeroxideNADPH OxidasesReactive Oxygen SpeciesTestosterone1′S-1′-acetoxychavicol acetateandrogenetic alopeciaNADPH oxidaseNox inhibitorreactive oxygen species

Identifiers

PMID40430418
PMCPMC12114461

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.