A Novel SERS Silent-Region Signal Amplification Strategy for Ultrasensitive Detection of Cu

Jiabin Su, Kaixin Chen, Ping Zhou, Nan Li

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Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Jiabin SuKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.

Kaixin ChenKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.ORCID 0000-0002-1987-3800

Ping ZhouKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.ORCID 0000-0002-2532-0954

Nan LiKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.ORCID 0000-0003-0188-0460

Funding

Guangdong Basic and Applied Basic Research Foundation 2023A1515011361, 2020A1515010957

6 · The paper itself

Abstract

Due to its unique molecular fingerprinting capability and multiplex detection advantages, surface-enhanced Raman scattering (SERS) has shown great application potential in the field of biological analysis. However, the weak signal intensity and large background interference significantly limited the application of SERS in biosensing and bioimaging. Loading a large amount of Raman molecules with signal in the silent region on the hotspots of the electromagnetic field of the SERS substrate can effectively avoid severe background noise signals and significantly improve the signal intensity, making the sensitivity and specificity of SERS detection remarkably improved. To achieve this goal, a new SERS signal-amplification strategy is herein reported for background-free detection of Cu

Indexed as

CopperSpectrum Analysis, RamanBiosensing TechniquesGoldLimit of DetectionMetal NanoparticlesCopperGoldCu2+ detectioncyanide functionalizationsignal amplification strategysilent region detectionsurface-enhanced Raman scattering

Identifiers

PMID40430360

DOI10.3390/molecules30102188

PMCPMC12114283

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.