Evidence map›Paper›PMID 40430274›Full record

ArticleMolecules (Basel, Switzerland)2025

Oxaloacetate and Ketone Bodies Synergistically Promote Myoblast Differentiation in L6 Cells.

Yuji Onuki, Naoki Nanashima, Yutaro Sasaki, Akiko Kojima-Yuasa, Toshio Norikura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuji OnukiGraduate School of Health Sciences, Aomori University of Health and Welfare, Aomori 030-8505, Japan.ORCID 0009-0007-7399-8800
Naoki NanashimaGraduate School of Health Sciences, Aomori University of Health and Welfare, Aomori 030-8505, Japan.ORCID 0000-0002-4729-3432
Yutaro SasakiGraduate School of Health Sciences, Aomori University of Health and Welfare, Aomori 030-8505, Japan.ORCID 0000-0002-1342-0659
Akiko Kojima-YuasaGraduate School of Human Life and Ecology, Osaka Metropolitan University, Osaka 558-8585, Japan.ORCID 0000-0001-8167-3693
Toshio NorikuraGraduate School of Health Sciences, Aomori University of Health and Welfare, Aomori 030-8505, Japan.ORCID 0000-0002-8285-2965

Funding

Japan Society for the Promotion of Science JP23K10892
6 · The paper itself

Abstract

Malnutrition and aging are major factors that inhibit myoblast differentiation, leading to a decline in muscle function and contributing to sarcopenia development. This study aimed to elucidate the role of nutrients in myoblast differentiation by establishing a culture system at physiological glucose levels and investigating the effects of ketone bodies and oxaloacetate. We successfully cultured myoblasts at physiological glucose concentrations in a hydrophobic membrane filter-equipped culture flask. Under these conditions, ketone bodies and oxaloacetate synergistically upregulated myogenic differentiation markers (

Indexed as

Cell DifferentiationKetone BodiesMyoblastsAnimalsCell LineGlucoseMuscle DevelopmentPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsSignal TransductionGlucoseKetone BodiesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktdifferentiationketone bodiesmyoblastmyogenesismyotubeoxaloacetate

Identifiers

PMID40430274
PMCPMC12114476

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.