Evidence map›Paper›PMID 40430193›Full record

ArticleLife (Basel, Switzerland)2025

Tapping into Metabolomics for Understanding Host and Rotavirus Group A Interactome.

Phiona Moloi Mametja, Mmei Cheryl Motshudi, Clarissa Marcelle Naidoo, Kebareng Rakau, Luyanda Mapaseka Seheri, Nqobile Monate Mkolo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Phiona Moloi MametjaDepartment of Biology and Environmental Sciences, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.ORCID 0000-0003-3044-6161
Mmei Cheryl MotshudiDepartment of Biology and Environmental Sciences, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
Clarissa Marcelle NaidooDepartment of Biology and Environmental Sciences, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.ORCID 0000-0001-9164-8213
Kebareng RakauDiarrheal Pathogens Research Unit, Department of Virology, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
Luyanda Mapaseka SeheriDiarrheal Pathogens Research Unit, Department of Virology, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
Nqobile Monate MkoloDepartment of Biology and Environmental Sciences, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.ORCID 0000-0003-3631-4522

Funding

South African Medical Research Council RCDI MKOLO NM 24/26
6 · The paper itself

Abstract

Group A rotavirus continues to be a leading global etiological agent of severe gastroenteritis in young children under 5 years of age. The replication of this virus in the host is associated with the occurrence of Lewis antigens and the secretor condition. Moreover, histo-blood group antigens (HBGAs) act as attachment factors to the outer viral protein of VP4 for rotavirus. Therefore, in this study, we employed a metabolomic approach to reveal potential signature metabolic molecules and metabolic pathways specific to rotavirus P[8] strain infection (VP4 genotype), which is associated with the expression of HBGA combined secretor and Lewis (Le) phenotypes, specifically secretor/Le

Indexed as

butyratechildrenhisto-blood group antigensomicsrotavirus P[8] strain

Identifiers

PMID40430193
PMCPMC12113392

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.