ArticleLife (Basel, Switzerland)2025
The Cut-Off Value for the Triglyceride-Glucose Index (TyG) Discriminating Insulin Resistance Based on the SHBG Level and HOMA-IR Values in Women with Polycystic Ovary Syndrome.
Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations between the triglyceride‒glucose index and the odds of low muscle mass and sarcopenia: a systematic review and meta-analysis.BMC endocrine disorders · 2026Pooled it
- Clinical Obesity and Insulin Resistance Assessed Based on SHBG Levels and HOMA-IR, TyG-Waist Circumference (TyG-WC), TyG-Waist to Height Ratio (TyG-WHtR), and TyG-Waist to Hip Ratio (TyG-WHR) Values in Young Caucasian Women with Polyendocrine Metabolic Ovarian Syndrome (PMOS).Journal of clinical medicine · 2026Article
- Preoperative Triglyceride-Glucose Index as a Predictor of Weight Loss Following Sleeve Gastrectomy: A Retrospective Cohort Study.Obesity surgery · 2026Article
- Triglyceride-glucose index and assisted reproductive outcomes in non-PCOS women: evidence from a propensity score-weighted cohort of 9,903 patients.Journal of ovarian research · 2026Article
- The Cut-Off for Triglyceride-Glucose-Body Mass Index (TyG-BMI) and Triglyceride-Glucose-Waist Circumference Index (TyG-WC) Discriminating the Insulin Resistance Based on the SHBG Level and HOMA-IR Value in Caucasian Women with Polycystic Ovary Syndrome.Medicina (Kaunas, Lithuania) · 2026Article
- Review
- Association between the triglyceride-glucose index and risk of type 2 diabetes mellitus and the mediating effect of BMI: a comparative analysis in Chinese and Japanese populations.Frontiers in endocrinology · 2026Article
- A nomogram for predicting insulin resistance in polycystic ovary syndrome based on serum amino acid profiles and anti-Müllerian hormone.American journal of translational research · 2026Article
- The gut microbiota-metabolite axis in polycystic ovary syndrome: differential characteristics between infertile and conceived populations.Frontiers in microbiology · 2026Article
- Anthropometric and Metabolic Determinants of Multi-Organ Stress in Adults with Obesity: Application of the CaRaMeL-O Score.Healthcare (Basel, Switzerland) · 2025Article
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7 authors.
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Abstract
The triglyceride-glucose (TyG) index was recently suggested as a surrogate marker of liver steatosis and insulin resistance. However, the TyG index cut-off value may be affected by age, sex, and race. Therefore, this study aimed to estimate the cut-off value for the TyG index discriminating insulin resistance based on the previously established cut-offs for HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) and serum level of SHBG (sex hormone-binding globulin) in Caucasian women with polycystic ovary syndrome (PCOS). The medical records of 311 unselected Caucasian women diagnosed with PCOS were included. Finally, due to the exclusion of patients with diabetes and hypertension, a cohort of 264 (84.9%) women with PCOS were analyzed. The following data were retrieved from the medical history: age, body weight, waist circumference, height, serum levels of glucose, triglycerides, insulin, and SHBG. HOMA-IR was calculated with a standard formula. The TyG index was calculated according to the formula TyG = ln(triglycerides[mg/dL] × glucose [mg/dL]/2). The cut-off value for the TyG index was calculated using ROC analysis. The empirical optimal of the TyG index cut-off, corresponding to HOMA-IR ≥ 2.1, was >8.31 (AUC 0.77, accuracy 0.70, sensitivity 61.2%, specificity 75.3%, PPV-positive predictive value 59.4%, NPV-negative predictive value 76.7%). The corresponding TyG index cut-off values for a SHBG level < 41.5 nmol/L was >8.31 (AUC 0.67, accuracy 0.65, sensitivity 54.9%, specificity 73.9%, PPV 64.4%, NPV 65.6%). Our study suggests that the cut-off point for the TyG index in young Caucasian women with PCOS, which discriminates against insulin resistance, is 8.31 (based on both HOMA-IR and SHBG values). In addition, our data confirm the usefulness of the TyG index as an initial assessment of insulin resistance, which should be confirmed by assessing the HOMA-IR value or SHBG concentration.
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