Evidence map›Paper›PMID 40430069›Full record

ArticleInternational journal of molecular sciences2025

Effects of Hormone Replacement Treatment with Estrogen and Progestins on the Vascular Renin-Angiotensin System of Ovariectomized Rats.

Laís Almeida Menezes, Patrick Wander Endlich, Deiviany Santana Santos Lima, A Augusto Peluso, Simone Alves de Almeida, Mariana Veronez Borgo, Robson Augusto Souza Santos, Glaucia Rodrigues de Abreu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Laís Almeida MenezesDepartment of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória 29043-900, Brazil.
Patrick Wander EndlichMucuri School of Medicine, Post-Graduate Program in Health Sciences, Federal University of the Jequitinhonha and Mucuri Valleys, Teófilo Otoni 39803-371, Brazil.ORCID 0000-0002-7597-3603
Deiviany Santana Santos LimaMucuri School of Medicine, Post-Graduate Program in Health Sciences, Federal University of the Jequitinhonha and Mucuri Valleys, Teófilo Otoni 39803-371, Brazil.ORCID 0009-0008-4998-2259
A Augusto PelusoFaculty of Health and Medical Sciences, University of Copenhagen, 2300 Copenhagen, Denmark.ORCID 0000-0002-8653-2248
Simone Alves de AlmeidaDepartment of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória 29043-900, Brazil.
Mariana Veronez BorgoDepartment of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória 29043-900, Brazil.
Robson Augusto Souza SantosDepartment of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.ORCID 0000-0001-8738-5852
Glaucia Rodrigues de AbreuDepartment of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória 29043-900, Brazil.

Funding

Fundação de Amparo à Pesquisa do Espírito Santo 1016/2022 P:2022-ZQT66
6 · The paper itself

Abstract

The renin-angiotensin system (RAS) is the main endocrine and tissular component responsible for controlling cardiovascular homeostasis, which can be modulated by estrogen levels. This study investigated the effects of hormone treatments with estrogen and progestins on angiotensin-(1-7)-mediated [Ang-(1-7)] vasodilation in ovariectomized rats and the possible mechanisms involving the RAS. Female Wistar rats were divided into the following groups: sham (SHAM), ovariectomized (OVX), OVX and treated with 17β-estradiol (E2) (OE

Indexed as

EstradiolEstrogen Replacement TherapyEstrogensProgestinsRenin-Angiotensin SystemAndrostenesAngiotensin-Converting Enzyme 2Angiotensin IAngiotensin IIAnimalsAorta, ThoracicFemaleImidazolesNitric Oxide Synthase Type IIIOvariectomyPeptide FragmentsAce2 protein, ratAndrostenesAngiotensin-Converting Enzyme 2Angiotensin Iangiotensin I (1-7)Angiotensin IIdrospirenoneEstradiolEstrogensImidazolesNitric Oxide Synthase Type IIIPD 123319Peptide FragmentsPeptidyl-Dipeptidase AProgestinsProto-Oncogene MasProto-Oncogene ProteinsPyridinesReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2Receptors, G-Protein-Coupledcardiovascular regulationestrogen and progestinshormone therapyRAS

Identifiers

PMID40430069
PMCPMC12112500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.