Evidence map›Paper›PMID 40430062›Full record

ArticleInternational journal of molecular sciences2025

Structural Homology Fails to Predict Secretion Efficiency in

Ningning Wang, Yang Xiao, Xiyu Liu, Yuanqing Li, Dehua Yu, Jia Guo, Ping Lu, Xiaopeng Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Multicopy Expression of the Marine Antimicrobial Peptide SpgillcinProbiotics and antimicrobial proteins · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ningning WangInstitute of Physical Science and Information Technology, Anhui University, Hefei 230601, China.
Yang XiaoNanhu Laboratory, Jiaxing 314051, China.
Xiyu LiuLaboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing 100071, China.
Yuanqing LiNanhu Laboratory, Jiaxing 314051, China.
Dehua YuNanhu Laboratory, Jiaxing 314051, China.
Jia GuoNanhu Laboratory, Jiaxing 314051, China.
Ping LuNanhu Laboratory, Jiaxing 314051, China.
Xiaopeng ZhangLaboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing 100071, China.ORCID 0000-0002-0265-6471

Funding

National Nature Science Foundation of China 82173787
6 · The paper itself

Abstract

AI-driven biologics manufacturing demands an efficient protein production platform. In this study, we optimized scFv secretion in

Indexed as

Genetic EngineeringPichiaSaccharomycetalesSingle-Chain AntibodiesEndoplasmic ReticulumGene DosageGolgi ApparatusProtein TransportRecombinant ProteinsSecretory PathwayRecombinant ProteinsSingle-Chain Antibodiesexpression cassette designgene dosage optimizationPichia pastorisscFvsecretory pathway engineering

Identifiers

PMID40430062
PMCPMC12120847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.