Evidence map›Paper›PMID 40430042›Full record

ArticleInternational journal of molecular sciences2025

Caveolin-1 Deficiency in Macrophages Alleviates Carbon Tetra-Chloride-Induced Acute Liver Injury in Mice.

Ruirui Li, Yixue Shu, Yulin Yan, Junyi Zhu, Zilu Cheng, Jie Zhang, Liming Zhu, Yanhua Qiao, Quan Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruirui LiDepartment of Laboratory Animal Science, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Yixue ShuDepartment of Laboratory Animal Science, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Yulin YanDepartment of Laboratory Animal Science, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Junyi ZhuDepartment of Laboratory Animal Science, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.ORCID 0009-0000-7781-0034
Zilu ChengDepartment of Laboratory Animal Science, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.ORCID 0009-0004-0643-3162
Jie ZhangLaboratory Animal Center, Capital Medical University, Beijing 100069, China.
Liming ZhuLaboratory Animal Center, Capital Medical University, Beijing 100069, China.
Yanhua QiaoLaboratory Animal Center, Capital Medical University, Beijing 100069, China.
Quan SunDepartment of Laboratory Animal Science, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.

Funding

Natural Science Foundation of Beijing, China 7222009
6 · The paper itself

Abstract

Bone marrow-derived macrophages (BMMs) exhibit dynamic behavior and functional capabilities in response to specific microenvironmental stimuli. Recent investigations have proved that BMMs play crucial roles in promoting necrotic lesion resolution. Despite substantial advancements in understanding their activation and interaction with injured livers, researchers face challenges to develop effective treatments based on manipulating BMMs function. Caveolin-1 (Cav-1) is the major structural protein on the plasma membrane. We previously reported that Cav-1 knockout (KO) mice exhibited less functional damage and necrosis in carbon tetrachloride (CCl

Indexed as

Caveolin 1Chemical and Drug Induced Liver InjuryMacrophagesAnimalsCarbon TetrachlorideDisease Models, AnimalLiverMaleMiceMice, Inbred C57BLMice, KnockoutNecrosisSignal TransductionSTAT3 Transcription FactorCarbon TetrachlorideCav1 protein, mouseCaveolin 1STAT3 Transcription Factoracute liver injurybone marrow-derived macrophagesCaveolin-1hepatocellular necrosis and apoptosisM2 polarization

Identifiers

PMID40430042
PMCPMC12112502

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.