Evidence map›Paper›PMID 40430040›Full record

ArticleInternational journal of molecular sciences2025

Inhibition of MCP1 (CCL2) Enhances Antitumor Activity of NK Cells Against HCC Cells Under Hypoxia.

Hwan Hee Lee, Juhui Kim, Eunbi Park, Hyojeung Kang, Hyosun Cho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hwan Hee LeeCollege of Pharmacy, Duksung Women's University, Seoul 01369, Republic of Korea.
Juhui KimCollege of Pharmacy, Duksung Women's University, Seoul 01369, Republic of Korea.
Eunbi ParkCollege of Pharmacy, Duksung Women's University, Seoul 01369, Republic of Korea.
Hyojeung KangVessel-Organ Interaction Research Center, VOICE (MRC), Cancer Research Institute, College of Pharmacy, Kyungpook National University, Daegu 41566, Republic of Korea.ORCID 0000-0002-0622-5839
Hyosun ChoCollege of Pharmacy, Duksung Women's University, Seoul 01369, Republic of Korea.ORCID 0000-0001-9131-5742

Funding

National Research Foundation of Korea 2016R1A6A1A03007648National Research Foundation of Korea 2020R1A5A2017323National Research Foundation of Korea 2022R1I1A1A01066903
6 · The paper itself

Abstract

Hypoxia, a low-oxygen state, is a common feature of solid tumors. MCP1 (CCL2) is a small cytokine that is closely related to hypoxia and has a positive effect on tumor development. Hypoxia causes resistance to various treatments for solid tumors and the evasion of cancer immune surveillance by lymphocytes. Natural killer (NK) cells are innate lymphocytes that play an important role in cancer development, particularly in the liver. First, it was found that the incubation of HCC in hypoxia (2-5% O

Indexed as

Carcinoma, HepatocellularChemokine CCL2Killer Cells, NaturalLiver NeoplasmsAnimalsCell HypoxiaCell Line, TumorCell MovementHumansHypoxia-Inducible Factor 1, alpha SubunitMiceSTAT3 Transcription FactorCCL2 protein, humanChemokine CCL2Hypoxia-Inducible Factor 1, alpha SubunitSTAT3 Transcription Factorhuman hepatocellular carcinoma (HCC)hypoxiaMCP1 (CCL2)natural killer (NK) celltumor microenvironment

Identifiers

PMID40430040
PMCPMC12111856

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.