Therapeutic Potential of Quadrigemine I Against Lymphoma: Mechanistic Insights from Cell Lines and Xenograft Models Demonstrating DNA Damage, Oxidative Stress, and Pathway Regulation.

Junmei Pu, Wenfeng Shi, Jiabao Cui, Hui Yang, Jianxin Cao, Yaping Liu, Shanshan Xiao, Guiguang Cheng

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junmei PuFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.

Wenfeng ShiFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.

Jiabao CuiFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.

Hui YangFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.

Jianxin CaoFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.

Yaping LiuFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.

Shanshan XiaoFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.ORCID 0009-0005-7566-9651

Guiguang ChengFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.ORCID 0000-0002-5553-8399

Funding

National Natural Science Foundation of China 32260108Scientific Research Fund Project of Yunnan Provincial Department of Education 2024J0081Yunnan Fundamental Research Projects 202501AT070352 and 202401CF070107

6 · The paper itself

Abstract

Lymphoma is one of the malignant tumors that significantly threatens human health. Quadrigemine I, an indole alkaloid derived from the leaves of

Indexed as

DNA DamageIndole AlkaloidsLymphomaOxidative StressAnimalsApoptosisCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMiceReactive Oxygen SpeciesSignal TransductionXenograft Model Antitumor AssaysIndole AlkaloidsReactive Oxygen Specieslymphomaquadrigemine IRNA-seq analysisxenograft mice

Identifiers

PMID40429988

DOI10.3390/ijms26104848

PMCPMC12112571

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.