Evidence map›Paper›PMID 40429979›Full record

ArticleInternational journal of molecular sciences2025

Persistent Transcriptome Alterations in Zebrafish Embryos After Discontinued Opioid Exposure.

Ryan J North, Gwendolyn Cooper, Lucas Mears, Brian Bothner, Mensur Dlakić, Christa S Merzdorf

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ryan J NorthDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717, USA.ORCID 0009-0008-8948-5572
Gwendolyn CooperDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.
Lucas MearsDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717, USA.
Brian BothnerDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.ORCID 0000-0003-1295-9609
Mensur DlakićDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717, USA.ORCID 0000-0003-4315-1514
Christa S MerzdorfDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717, USA.

Funding

MONTANA INBRE Technology AccessMSU College of Agriculture minigrantU.S. National Science Foundation HRD-2054276
6 · The paper itself

Abstract

Much attention has been paid to the public health crisis that has resulted from the opioid epidemic. Given the high number of opioid users that are of childbearing age, the impact of utero exposure is a serious concern. Unfortunately, there is little knowledge regarding the consequences of opioid exposure during early development. While neurobehavioral effects of opioid exposure are well-documented, effects of exposure on embryogenesis remain largely unexplored. To address this gap in knowledge, we investigated the effects of oxycodone and fentanyl exposure on gene expression in zebrafish (

Indexed as

Analgesics, OpioidEmbryo, NonmammalianGene Expression Regulation, DevelopmentalTranscriptomeZebrafishAnimalsEmbryonic DevelopmentFentanylGene Expression ProfilingOxycodoneAnalgesics, OpioidFentanylOxycodonecrystallindevelopmentECM disruptionfentanyllow-doseneurodevelopmentopioidsoxycodoneRNA-seqtranscriptomicsvisual developmentzebrafish

Identifiers

PMID40429979
PMCPMC12111994

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.