Evidence map›Paper›PMID 40429963›Full record

ArticleInternational journal of molecular sciences2025

Opposing Calcium-Dependent Effects of GsMTx4 in Acute Lymphoblastic Leukemia: In Vitro Proliferation vs. In Vivo Survival Advantage.

Souleymane Abdoul-Azize, Rachid Zoubairi, Olivier Boyer

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Souleymane Abdoul-AzizeUMR 1234, Inserm, Univ Rouen Normandie, 22 Boulevard Gambetta, F-76000 Rouen, France.
Rachid ZoubairiUMR 1234, Inserm, Univ Rouen Normandie, 22 Boulevard Gambetta, F-76000 Rouen, France.
Olivier BoyerUMR 1234, Inserm, Univ Rouen Normandie, 22 Boulevard Gambetta, F-76000 Rouen, France.ORCID 0000-0002-7591-307X

Funding

La Ligue Contre le Cancer AK/IP/BC/16094/16792, IP/BC-17040
6 · The paper itself

Abstract

Mechanogated (MG) ion channels play a crucial role in mechano-transduction and immune cell regulation, yet their impact on blood cancers, particularly acute lymphoblastic leukemia (ALL), remains poorly understood. This study investigates the pharmacological effects of GsMTx4, an MG channel inhibitor, in human ALL cells both in vitro and in vivo. Unexpectedly, we found that GsMTx4 remarkably increased basal calcium (Ca

Indexed as

CalciumPrecursor Cell Lymphoblastic Leukemia-LymphomaAnimalsCalcium SignalingCell Line, TumorCell ProliferationCell SurvivalHumansMiceMice, Inbred NODCalciumALLCa2+ signalingcell survivalGsMTx4

Identifiers

PMID40429963
PMCPMC12112700

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.