Evidence map›Paper›PMID 40429949›Full record

ArticleInternational journal of molecular sciences2025

Effect of Warfarin on Lifespan and Oxidative Stress Tolerance of

Anna Lavrenova, Oleg Klychnikov, Vitaliy Ioutsi, Igor Rodin, Oksana Luneva, Lidia Nefedova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Sex-Related Effect of Chronic Doses of Warfarin and Menadione onInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anna LavrenovaDepartment of Genetics, Faculty of Biology, M. V. Lomonosov Moscow State University, 119234 Moscow, Russia.ORCID 0009-0005-7217-6667
Oleg KlychnikovDepartment of Biochemistry, Faculty of Biology, M. V. Lomonosov Moscow State University, 119234 Moscow, Russia.ORCID 0000-0002-0383-9237
Vitaliy IoutsiThe National Medical Research Center for Endocrinology, 117292 Moscow, Russia.
Igor RodinDepartment of Analytical Chemistry, Faculty of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russia.
Oksana LunevaDepartment of Biophysics, Faculty of Biology, M. V. Lomonosov Moscow State University, 119234 Moscow, Russia.
Lidia NefedovaDepartment of Genetics, Faculty of Biology, M. V. Lomonosov Moscow State University, 119234 Moscow, Russia.

Funding

MSU Program of Development 23-SCH-04-34
6 · The paper itself

Abstract

In vertebrates, vitamin K is a cofactor for the gamma-glutamyl carboxylase (GGCX) involved in the carboxylation of glutamic acid residues. During the vitamin K cycle, vitamin K is oxidised by GGCX, and then reduced by vitamin K epoxide reductase (VKOR), which is inhibited by the synthetic coumarin warfarin. GGCX and VKOR are present in

Indexed as

Drosophila melanogasterLongevityOxidative StressWarfarinAnimalsDrosophila ProteinsReactive Oxygen SpeciesVitamin KVitamin K 3Drosophila ProteinsReactive Oxygen SpeciesVitamin KVitamin K 3Warfarindrosophilavitamin Kwarfarin

Identifiers

PMID40429949
PMCPMC12112360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.