Additive Value of Rheumatoid Factor Isotypes in Sjögren's Syndrome Patients with Joint Complaints of Different Etiologies-Can Rheumatoid Factor IgA Serve as an Early, Poor Prognostic Biomarker Candidate?

Zsófia Aradi, Bernadett Bói, Gábor Nagy, Péter Antal-Szalmás, Kincső Mezei, Ildikó Fanny Horváth, Antónia Szántó

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Immunological profiling of rheumatoid factor-positive primary Sjögren's syndrome by single-cell RNA sequencing.Frontiers in immunology · 2026
Article
Rheumatoid Factor Beyond Rheumatoid Arthritis: A Potential Marker of Cardiometabolic and Hepatic Risk.Biologics : targets & therapy · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zsófia AradiDivision of Clinical Immunology, Institute of Internal Medicine, Faculty of Medicine, University of Debrecen, 22 Móricz Zsigmond Street, H-4032 Debrecen, Hungary.

Bernadett BóiDepartment of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, Kassai út 26, H-4028 Debrecen, Hungary.

Gábor NagyDepartment of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt 98, H-4032 Debrecen, Hungary.ORCID 0000-0002-2943-2750

Péter Antal-SzalmásDepartment of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt 98, H-4032 Debrecen, Hungary.

Kincső MezeiDivision of Clinical Immunology, Institute of Internal Medicine, Faculty of Medicine, University of Debrecen, 22 Móricz Zsigmond Street, H-4032 Debrecen, Hungary.

Ildikó Fanny HorváthDivision of Clinical Immunology, Institute of Internal Medicine, Faculty of Medicine, University of Debrecen, 22 Móricz Zsigmond Street, H-4032 Debrecen, Hungary.

Antónia SzántóDivision of Clinical Immunology, Institute of Internal Medicine, Faculty of Medicine, University of Debrecen, 22 Móricz Zsigmond Street, H-4032 Debrecen, Hungary.ORCID 0000-0002-4850-3737

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the paper was to characterize rheumatoid factor IgA, IgG, and IgM isotypes in patients with Sjögren's syndrome (SS) subsets, based on the absence or presence of joint complaints of different etiologies. In total, 164 SS patients were grouped based on whether they had polyarthritis as an extraglandular manifestation (

Indexed as

Immunoglobulin ARheumatoid FactorSjogren's SyndromeAdultAgedArthritis, RheumatoidBiomarkersFemaleHumansImmunoglobulin GImmunoglobulin MMaleMiddle AgedPrognosisBiomarkersImmunoglobulin AImmunoglobulin GImmunoglobulin MRheumatoid Factorbiomarkerpolyarthritisrheumatoid arthritisrheumatoid factorrheumatoid factor isotypesSjögren’s syndrome

Identifiers

PMID40429937

DOI10.3390/ijms26104797

PMCPMC12112740

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.