Evidence map›Paper›PMID 40429928›Full record

ArticleInternational journal of molecular sciences2025

Rutin Attenuates H

Hongyan Ding, Weizhe Yan, Daoliang Zhang, Lei Wang, Yue Yang, Chang Zhao, Shibin Feng, Xichun Wang, Jishun Tang, Dong Wu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hongyan DingCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, China.
Weizhe YanCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, China.
Daoliang ZhangCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, China.
Lei WangCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, China.
Yue YangCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, China.
Chang ZhaoCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, China.ORCID 0000-0001-8668-0171
Shibin FengCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, China.
Xichun WangCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, China.ORCID 0000-0001-5096-3970
Jishun TangAnhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Institute of Animal Science and Veterinary Medicine, Anhui Academy of Agricultural Sciences, Hefei 230001, China.
Dong WuAnhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Institute of Animal Science and Veterinary Medicine, Anhui Academy of Agricultural Sciences, Hefei 230001, China.
Jinjie WuCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, China.
Yu LiCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, China.ORCID 0000-0002-9886-4952

Funding

Anhui Province Key Laboratory of Animal Nutrition Regulation and Health APKLANRH202003National Natural Science Foundation of China 31873029National Natural Science Foundation of China 32172924National Science Foundation for Young Scientists of China 3220190315Science Fund for Excellent Young Scholars of Anhui Province 2208085Y13The Scientific Research Project of Academic, and the Technical Leader Reserve Candidate in Anhui Province 2022H283
6 · The paper itself

Abstract

Transition dairy cows face severe oxidative stress that disrupts mammary epithelial homeostasis through intertwined oxidative, inflammatory, and endoplasmic reticulum (ER) stress pathways. This study hypothesized that rutin, a natural flavonoid, alleviates hydrogen peroxide (H

Indexed as

AMP-Activated Protein KinasesApoptosisEndoplasmic Reticulum StressEpithelial CellsHydrogen PeroxideInflammationMammary Glands, AnimalNF-E2-Related Factor 2Oxidative StressRutinSignal TransductionAnimalsAntioxidantsCattleFemaleReactive Oxygen SpeciesAMP-Activated Protein KinasesAntioxidantsHydrogen PeroxideNF-E2-Related Factor 2Reactive Oxygen SpeciesRutinAMPK/NFE2L2 signaling pathwayapoptosisendoplasmic reticulum stressinflammatoryoxidative stressrutin

Identifiers

PMID40429928
PMCPMC12112555

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.