ArticleInternational journal of molecular sciences2025
Salivary Zinc and Copper Levels Are Differentially Associated with ROS Levels in Breast Cancer Patients.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Association of Serum Zinc Status with 5-Year Clinical Outcomes in Women with Breast Cancer and Type 2 Diabetes: A Retrospective Cohort Study Using TriNetX.Healthcare (Basel, Switzerland) · 2026Article
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3 authors.
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Abstract
Disruption of the balanced metabolism of copper and zinc can be both a consequence and potential cause-trigger for the occurrence of many pathological conditions including cancer. Zinc is an important cofactor of many enzymes that participate in inflammatory and redox reactions and the immune response, and refers to the components of DNA transcription factors. Copper plays an important role in processes such as cuproplasia and cuproptosis, affecting the process of cell differentiation and the epithelial-mesenchymal transition of cancer cells. In this regard, the study of changes in copper and zinc in breast cancer can provide valuable information on the metabolic features of cancer cells. In this study, we investigated the metabolic relationship between the zinc and copper levels in the saliva of patients with breast cancer and the content of reactive oxygen species, the state of the antioxidant and immune systems as well as the metabolism of the amino acids Cys, His, Met, and Arg. We also considered how the content and ratio of copper and zinc in saliva changes in patients with breast cancer depend on the state of the hormonal background and the expression of hormone receptors.
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