ReviewInternational journal of molecular sciences2025
Phytochelatins and Cadmium Mitigation: Harnessing Genetic Avenues for Plant Functional Manipulation.
Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- γ-Aminobutyric Acid Alleviates Cadmium Toxicity and Is Associated with Increased Ascorbate and Glutathione Levels inInternational journal of molecular sciences · 2026Article
- Transporter promiscuity and redox-driven metal partitioning in plant responses to chemically analogous metals.Plant cell reports · 2026Review
- Frontiers in cadmium mitigation: harnessing Nitrate Transporter 1 (NRT1) for plant systems.Planta · 2026Review
- Functional Genetic Frontiers in Plant ABC Transporters: Avenues Toward Cadmium Management.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Among the highly toxic heavy metals, cadmium (Cd) is highlighted as a persistent environmental pollutant, posing serious threats to plants and broader ecological systems. Phytochelatins (PCs), which are synthesized by phytochelatin synthase (PCS), are peptides that play a central role in Cd mitigation through metal chelation and vacuolar sequestration upon formation of Cd-PC complexes. PC synthesis interacts with other cellular mechanisms to shape detoxification outcomes, broadening the functional scope of PCs beyond classical stress responses. Plant Cd-related processes have has been extensively investigated within this context. This perspective article presents key highlights of the panorama concerning strategies targeting the PC pathway and PC synthesis to manipulate Cd-exposed plants. It discusses multiple advances on the topic related to genetic manipulation, including the use of mutants and transgenics, which also covers gene overexpression, PCS-deficient and PCS-overexpressing plants, and synthetic PC analogs. A complementary bibliometric analysis reveals emerging trends and reinforces the need for interdisciplinary integration and precision in genetic engineering. Future directions include the design of multigene circuits and grafting-based innovations to optimize Cd sequestration and regulate its accumulation in plant tissues, supporting both phytoremediation efforts and food safety in contaminated agricultural environments.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.