Evidence map›Paper›PMID 40429876›Full record

ArticleInternational journal of molecular sciences2025

Anti-IL-4, Anti-IL-17, and Anti-IFN-Gamma Activity in the Saliva of

Helioswilton Sales-Campos, Chamberttan Souza Desidério, Rafael Obata Trevisan, Rodolfo Pessato Timóteo, Victor Hugo Palhares Flávio-Reis, Yago Marcos Pessoa-Gonçalves, Marcos Vinicius da Silva, Eliane Esteves, Thiago de Jesus Oliveira, Pedro Ismael da Silva Junior and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Helioswilton Sales-CamposDepartment of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiania 74605-050, Goiás, Brazil.ORCID 0000-0003-3252-2834
Chamberttan Souza DesidérioDepartment of Microbiology, Immunology and Parasitology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba 38025-180, Minas Gerais, Brazil.ORCID 0000-0003-4399-0633
Rafael Obata TrevisanDepartment of Microbiology, Immunology and Parasitology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba 38025-180, Minas Gerais, Brazil.ORCID 0000-0002-4509-9142
Rodolfo Pessato TimóteoDepartment of Microbiology, Immunology and Parasitology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba 38025-180, Minas Gerais, Brazil.ORCID 0000-0002-4273-8201
Victor Hugo Palhares Flávio-ReisDepartment of Microbiology, Immunology and Parasitology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba 38025-180, Minas Gerais, Brazil.ORCID 0009-0007-9578-1258
Yago Marcos Pessoa-GonçalvesDepartment of Microbiology, Immunology and Parasitology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba 38025-180, Minas Gerais, Brazil.ORCID 0000-0002-9598-6276
Marcos Vinicius da SilvaDepartment of Microbiology, Immunology and Parasitology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba 38025-180, Minas Gerais, Brazil.ORCID 0000-0002-2966-7621
Eliane EstevesLaboratory of Infectious Diseases, Department of Microbiology and Immunology, University of South Alabama, Mobile, AL 36688, USA.ORCID 0000-0002-4347-798X
Thiago de Jesus OliveiraLaboratory for Applied Toxinology (LETA), Butantan Institute, São Paulo 05585-000, São Paulo, Brazil.
Pedro Ismael da Silva JuniorLaboratory for Applied Toxinology (LETA), Butantan Institute, São Paulo 05585-000, São Paulo, Brazil.ORCID 0000-0001-6619-6489
Carlo José Freire OliveiraDepartment of Microbiology, Immunology and Parasitology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba 38025-180, Minas Gerais, Brazil.ORCID 0000-0003-2211-7333

Funding

Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ02783-17 and RED-00313-16Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular 465678/2014-9
6 · The paper itself

Abstract

The saliva of hematophagous arthropods, such as ticks and triatomines, contains bioactive ligands capable of modulating immune molecules, including cytokines. Cytokines play a critical role in immune regulation and have therapeutic relevance in inflammatory and immune-mediated diseases. Despite recent advances, identifying cytokine-binding molecules remains a significant challenge. Interferon-gamma (IFN-γ), interleukin-4 (IL-4), and interleukin-17 (IL-17) are key cytokines involved in inflammation, adaptive immunity, and host defense. This study evaluated the ability of salivary components from

Indexed as

AmblyommaInterferon-gammaInterleukin-17Interleukin-4SalivaAnimalsCytokinesHumansCytokinesInterferon-gammaInterleukin-17Interleukin-4Amblyomma sculptumcytokine-binding proteinsimmunomodulationsalivaticks

Identifiers

PMID40429876
PMCPMC12112547

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.