Evidence map›Paper›PMID 40429849›Full record

ArticleInternational journal of molecular sciences2025

Structural Implications of H233L and H398P Mutations in Phospholipase Cζ: A Full-Atom Molecular Dynamics Study on Infertility-Associated Dysfunctions.

Fernando Hinostroza, Sofía Albornoz-Muñoz, Sebastián Vergara, Gabriela Urra, Ingrid Araya-Durán, Rafael A Fissore, Fernando Danilo González-Nilo, Daniel Bustos, Ingrid Carvacho

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fernando HinostrozaCentro de Investigación de Estudios Avanzados del Maule (CIEAM), Vicerrectoría de Investigación y Postgrado, Universidad Católica del Maule, Talca 3460000, Chile.
Sofía Albornoz-MuñozEscuela de Ingeniería en Biotecnología, Facultad de Ciencias Agrarias y Forestales, Universidad Católica del Maule, Talca 3460000, Chile.ORCID 0009-0002-9563-3515
Sebastián VergaraDepartamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca 3460000, Chile.
Gabriela UrraLaboratorio de Bioinformática y Química Computacional, Departamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca 3460000, Chile.ORCID 0009-0006-3871-0261
Ingrid Araya-DuránCenter for Bioinformatics and Integrative Biology (CBIB), Universidad Andrés Bello, Santiago 8370146, Chile.
Rafael A FissoreDepartment of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA.
Fernando Danilo González-NiloCenter for Bioinformatics and Integrative Biology (CBIB), Universidad Andrés Bello, Santiago 8370146, Chile.ORCID 0000-0001-6857-3575
Daniel BustosLaboratorio de Bioinformática y Química Computacional, Departamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca 3460000, Chile.ORCID 0000-0002-2136-2305
Ingrid CarvachoDepartamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca 3460000, Chile.ORCID 0000-0003-2311-7239

Funding

Agencia Nacional de Investigación y Desarrollo FONDECYT Regular 1221308Agencia Nacional de Investigación y Desarrollo Subvención a la Instalación a la Academia SA772100065
6 · The paper itself

Abstract

Phospholipase Cζ (PLCζ), a sperm-specific enzyme, plays a critical role in mammalian fertilization. Mutations in PLCζ have been linked to male infertility, as they impair its ability to trigger calcium (Ca

Indexed as

Infertility, MaleMolecular Dynamics SimulationMutationPhosphoinositide Phospholipase CCalciumHumansHydrogen BondingMalePhosphatidylinositol 4,5-DiphosphateCalciumPhosphatidylinositol 4,5-DiphosphatePhosphoinositide Phospholipase CPLCZ1 protein, humanH233L mutationH398P mutationinfertilityphosphatidylinositol 4,5-bisphosphatePhospholipase CζR553P mutation

Identifiers

PMID40429849
PMCPMC12111915

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.