Evidence map›Paper›PMID 40429834›Full record

ArticleInternational journal of molecular sciences2025

A Biomimetic Adhesive/Kaolin Material with Strong Adhesion, Sealing, and Active Coagulation Function for Arterial Hemostasis.

Wanli Zhang, Junqin Mao, Aiping Yang, Tao Shen, Qiuyu Zeng, You Tang, Yan Du, Guoyu Lv, Heng Zheng, Hong Li

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wanli ZhangCollege of Physics, Sichuan University, Chengdu 610065, China.
Junqin MaoCollege of Physics, Sichuan University, Chengdu 610065, China.
Aiping YangCollege of Physics, Sichuan University, Chengdu 610065, China.
Tao ShenCollege of Physics, Sichuan University, Chengdu 610065, China.
Qiuyu ZengCollege of Physics, Sichuan University, Chengdu 610065, China.
You TangCollege of Physics, Sichuan University, Chengdu 610065, China.
Yan DuCollege of Information Engineering and Automation, Kunming University of Science and Technology, Kunming 650032, China.
Guoyu LvCollege of Physics, Sichuan University, Chengdu 610065, China.
Heng ZhengCollege of Physics, Sichuan University, Chengdu 610065, China.
Hong LiCollege of Physics, Sichuan University, Chengdu 610065, China.

Funding

Natural Science Foundation of Sichuan Province No. 2023NSFSC0328Sichuan Provincial Science and Technology Program No. 2024YFTX0038
6 · The paper itself

Abstract

Effective prehospital hemostasis is pivotal for improving survival outcomes in arterial hemorrhage. Existing hemostatic materials have limitations in terms of both efficiency and portability, particularly under complex wound conditions. This study engineered a kaolin-reinforced biomimetic adhesive composite powder (DTG-K), which achieved dual hemostatic mechanisms: mechanical occlusion via strong interfacial adhesion (lap-shear strength of 58.3 kPa) and biochemical activation of the intrinsic coagulation pathway through factor XII. In vitro evaluations confirmed its exceptional hemocompatibility, with a 0.93% hemolysis rate. When applied to femoral artery hemorrhage models in Bama swine, DTG-K demonstrated complete hemostasis within 30 s through synergistic physical sealing and biochemical coagulation. These findings demonstrate the potential of DTG-K as an innovative strategy for managing life-threatening arterial hemorrhage in prehospital emergency scenarios.

Indexed as

AdhesivesBiomimetic MaterialsBlood CoagulationHemorrhageHemostasisHemostaticsKaolinAnimalsFemoral ArterySwineAdhesivesHemostaticsKaolinarterial hemorrhagebiomimetic adhesivekaolinstrong adhesion hemostasis

Identifiers

PMID40429834
PMCPMC12111511

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.