Evidence map›Paper›PMID 40429761›Full record

ArticleInternational journal of molecular sciences2025

Long-Term Functional and Structural Renoprotection After Experimental Acute Kidney Injury in Subclinical Chronic Kidney Disease In Vivo.

Sanjeeva Herath, Amy Y M Au, Kylie M Taylor, Natasha Kapoor-Kaushik, Zoltán H Endre, Jonathan H Erlich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sanjeeva HerathSchool of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-4931-6271
Amy Y M AuSchool of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.
Kylie M TaylorSchool of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.
Natasha Kapoor-KaushikElectron Microscopy Unit, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0001-8616-592X
Zoltán H EndreSchool of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-4782-8695
Jonathan H ErlichSchool of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-4447-2179

Funding

Prince of Wales Hospital Foundation and Lewis Foundation none
6 · The paper itself

Abstract

Subclinical chronic kidney disease (sCKD) predisposes one to acute kidney injury (AKI) and chronic kidney disease (CKD). Reduced kidney functional reserve (KFR) detects sCKD in preclinical studies and predicts AKI after cardiac surgery. We evaluated renal protection in a rat model of kidney injury where ischaemia-reperfusion injury (IRI) was induced after sCKD. Dual treatment boosting nicotinamide adenine dinucleotide (NAD) by nicotinamide riboside (NR) combined with the mitochondria-targeted antioxidant SkQR1 protected the KFR and reduced structural kidney damage, including markers of vascular integrity and the relative blood volume (rBV). The dual treatment upregulated

Indexed as

Acute Kidney InjuryRenal Insufficiency, ChronicAnimalsAntioxidantsDisease Models, AnimalKidneyMaleMitochondriaNADNF-E2-Related Factor 2NiacinamidePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPyridinium CompoundsRatsReperfusion InjurySirtuin 1AntioxidantsNADNF-E2-Related Factor 2Niacinamidenicotinamide-beta-ribosidePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPyridinium CompoundsSirtuin 1acute kidney diseasechronic kidney diseaseischaemia–reperfusion injurykidney functional reservemitochondrial protectionnicotinamide adenine dinucleotiderenoprotection

Identifiers

PMID40429761
PMCPMC12111561

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.