Evidence map›Paper›PMID 40429702›Full record

ArticleInternational journal of molecular sciences2025

NetLnc: A Network-Based Computational Framework to Identify Immune Checkpoint-Related lncRNAs for Immunotherapy Response in Melanoma.

Qianyi Lu, Jian Li, Wenli Chen, Zhuoru Wang, Di Wang, Chenyu Liu, Yue Sun, Han Jiang, Caiyu Zhang, Yetong Chang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qianyi LuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
Jian LiCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
Wenli ChenCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
Zhuoru WangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
Di WangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
Chenyu LiuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.ORCID 0009-0004-2937-5735
Yue SunCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
Han JiangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
Caiyu ZhangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
Yetong ChangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
Jiajun ZhouCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
Xiaohong WuNHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University, Harbin 150081, China.
Yue GaoCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
Shangwei NingCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.ORCID 0000-0003-4079-8945

Funding

National Natural Science Foundation of China [32370718, 32070672, 32100528]
6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) could alter the tumor immune microenvironment and regulate the expression of immune checkpoints (ICPs) by regulating target genes in tumors. However, only a few lncRNAs have precise functions in immunity and potential for predicting ICP inhibitors (ICI) response. Here, we developed a computational multi-step framework that leverages interaction network-based analysis to identify cancer- and immune-context ICP-related lncRNAs (NetLnc). Based on bulk and single-cell RNA sequencing data, these lncRNAs were significantly correlated with immune cell infiltration and immune expression signature. Specific hub ICP-related lncRNAs such as

Indexed as

Computational BiologyImmunotherapyMelanomaRNA, Long NoncodingBiomarkers, TumorGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansImmune Checkpoint InhibitorsMachine LearningPrognosisTumor MicroenvironmentBiomarkers, TumorImmune Checkpoint InhibitorsRNA, Long Noncodingbiomarkerimmune checkpointimmunotherapylong non-coding RNAmelanoma

Identifiers

PMID40429702
PMCPMC12110832

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.