Evidence map›Paper›PMID 40429683›Full record

ArticleInternational journal of molecular sciences2025

Extended Family of Thiophosphoryl-Appended Pd(II) Pincer Complexes with a Deprotonated Amide Core: Synthesis and Biological Evaluation.

Diana V Aleksanyan, Svetlana G Churusova, Aleksandr V Konovalov, Ekaterina Yu Rybalkina, Lidia A Laletina, Yana V Ryzhmanova, Yulia V Nelyubina, Svetlana A Soloveva, Sergey E Lyubimov, Alexander S Peregudov and 2 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Diana V AleksanyanA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Str. 1, Moscow 119334, Russia.
Svetlana G ChurusovaA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Str. 1, Moscow 119334, Russia.
Aleksandr V KonovalovA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Str. 1, Moscow 119334, Russia.
Ekaterina Yu RybalkinaN. N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation, Kashirskoe Shosse 23, Moscow 115478, Russia.
Lidia A LaletinaN. N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation, Kashirskoe Shosse 23, Moscow 115478, Russia.ORCID 0000-0002-8839-5881
Yana V RyzhmanovaSkryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino Scientific Center of Biological Research, Russian Academy of Sciences, pr. Nauki 5, Pushchino 142292, Russia.ORCID 0000-0003-2987-5604
Yulia V NelyubinaA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Str. 1, Moscow 119334, Russia.ORCID 0000-0002-9121-0040
Svetlana A SolovevaA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Str. 1, Moscow 119334, Russia.
Sergey E LyubimovA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Str. 1, Moscow 119334, Russia.
Alexander S PeregudovA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Str. 1, Moscow 119334, Russia.
Zinaida S KlemenkovaA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Str. 1, Moscow 119334, Russia.
Vladimir A KozlovA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Str. 1, Moscow 119334, Russia.

Funding

Ministry of Health of the Russian Federation 123021500068-8 NUYO-2023-0009Ministry of Science and Higher Education of the Russian Federation 075-00276-25-00Russian Science Foundation 22-73-10044
6 · The paper itself

Abstract

The development of new, more effective, and selective anticancer agents is one of the most important tasks of modern medicinal chemistry. Recently, we have found that non-classical Pd(II) pincer complexes derived from thiophosphoryl-appended picolinamides exhibit promising cytotoxic properties. In this work, the potential of this class of metal-based derivatives was studied on an extended family of Pd(II) complexes with a deprotonated amide core featuring thiophosphoryl pendant arms, readily obtained by the direct cyclopalladation of new functionalized amide ligands upon interaction with PdCl

Indexed as

AmidesAntineoplastic AgentsCoordination ComplexesPalladiumAnti-Bacterial AgentsApoptosisCell Line, TumorExtended FamilyHumansLigandsMicrobial Sensitivity TestsAmidesAnti-Bacterial AgentsAntineoplastic AgentsCoordination ComplexesLigandsPalladiumantibacterial activitycytotoxicitymetal-based drugspalladiumpincer complexes

Identifiers

PMID40429683
PMCPMC12111564

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.