Evidence map›Paper›PMID 40429662›Full record

ArticleInternational journal of molecular sciences2025

Unveiling the Multifaceted Role of HP6: A Critical Regulator of Humoral Immunity in

Chengbao Liu, Jinzhu Yu, Ting Fu, Xueshan He, Lin Zhao, Xialu Wang, Rong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chengbao LiuSchool of Life Science and Bio-Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Jinzhu YuSchool of Life Science and Bio-Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Ting FuSchool of Life Science and Bio-Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Xueshan HeSchool of Life Science and Bio-Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Lin ZhaoSchool of Life Science and Bio-Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Xialu WangSchool of Medical Devices, Shenyang Pharmaceutical University, Shenyang 110016, China.
Rong ZhangSchool of Life Science and Bio-Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.

Funding

2023 Liaoning Provincial Applied Basic Research Program 2023JH2/101300107the Outstanding Youth Support Program of Shenyang Pharmaceutical University YQ202115
6 · The paper itself

Abstract

Serine proteases are widely distributed in both invertebrates and vertebrates, playing critical roles in the regulation of innate immunity. In the insect innate immune system, two pivotal pathways-the prophenoloxidase (PPO) activation cascade and Toll pathway-mediated antimicrobial peptide (AMP) synthesis-are both tightly regulated by serine protease cascades. This study focuses on serine protease-hemolymph protease 6 of

Indexed as

Immunity, HumoralInsect ProteinsMothsSerine ProteasesAnimalsAntimicrobial PeptidesCatechol OxidaseEnzyme PrecursorsFat BodyHemocytesHemolymphImmunity, InnateLarvaRNA InterferenceAntimicrobial PeptidesCatechol OxidaseEnzyme PrecursorsInsect Proteinspro-phenoloxidaseSerine ProteasesAMP synthesisAntheraea pernyihumoral immunePPO-activation systemserine protease

Identifiers

PMID40429662
PMCPMC12111086

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.