Evidence map›Paper›PMID 40429618›Full record

ArticleInternational journal of molecular sciences2025

Differential Effects of Sphingolipids on Cell Death and Antioxidant Defenses in Type 1 and Type 2 Endometrial Cancer Cells.

Agnieszka U Błachnio-Zabielska, Patrycja Sadowska, Urszula Chlabicz, Karolina Pogodzińska, Hervé Le Stunff, Piotr Laudański, Jacek Szamatowicz, Mariusz Kuźmicki

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Agnieszka U Błachnio-ZabielskaDepartment of Hygiene, Epidemiology and Metabolic Disorders, Medical University of Bialystok, 15-089 Bialystok, Poland.ORCID 0000-0002-8055-0576
Patrycja SadowskaDepartment of Hygiene, Epidemiology and Metabolic Disorders, Medical University of Bialystok, 15-089 Bialystok, Poland.
Urszula ChlabiczDepartment of Hygiene, Epidemiology and Metabolic Disorders, Medical University of Bialystok, 15-089 Bialystok, Poland.
Karolina PogodzińskaDepartment of Hygiene, Epidemiology and Metabolic Disorders, Medical University of Bialystok, 15-089 Bialystok, Poland.
Hervé Le StunffCNRS UMR 9197, Institut des Neurosciences Paris-Saclay, Université Paris-Saclay, 91400 Saclay, France.ORCID 0000-0003-4618-7838
Piotr LaudańskiDepartment of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, 02-091 Warsaw, Poland.
Jacek SzamatowiczDepartment of Gynecology and Gynecological Oncology, Medical University of Bialystok, 15-089 Bialystok, Poland.
Mariusz KuźmickiDepartment of Gynecology and Gynecological Oncology, Medical University of Bialystok, 15-089 Bialystok, Poland.

Funding

Medical University of Bialystok B.SUB.24.415
6 · The paper itself

Abstract

Endometrial cancer (EC) is classified into two main subtypes with distinct molecular profiles. Sphingolipids, particularly ceramide and sphingosine-1-phosphate (S1P), are crucial regulators of cell survival, apoptosis, and oxidative stress. This study examined the impact of sphingolipid metabolism in Ishikawa (type 1) and HEC-1A (type 2) EC cells following the silencing of

Indexed as

AntioxidantsEndometrial NeoplasmsSphingolipidsApoptosisCell DeathCell Line, TumorCell SurvivalCeramidesFemaleHumansLysophospholipidsMembrane Potential, MitochondrialOxidative StressReactive Oxygen SpeciesSerine C-PalmitoyltransferaseSphingosineAntioxidantsCeramidesLysophospholipidsReactive Oxygen SpeciesSerine C-PalmitoyltransferaseSphingolipidsSphingosinesphingosine 1-phosphateSPTLC1 protein, humancell deathcell viabilityceramideendometrial cancersphingolipid rheostatsphingosine-1-phosphate

Identifiers

PMID40429618
PMCPMC12110862

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.