Evidence map›Paper›PMID 40429170›Full record

ReviewInsects2025

Medical Potential of Insect Symbionts.

Fanglei Fan, Zhengyan Wang, Qiong Luo, Zhiyuan Liu, Yu Xiao, Yonglin Ren

Abstract readReview
In one paragraph

Review in Insects, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fanglei FanSchool of Food and Strategic Reserves, Henan University of Technology, Zhengzhou 450001, China.
Zhengyan WangSchool of Food and Strategic Reserves, Henan University of Technology, Zhengzhou 450001, China.
Qiong LuoSchool of Food and Strategic Reserves, Henan University of Technology, Zhengzhou 450001, China.
Zhiyuan LiuSchool of Food and Strategic Reserves, Henan University of Technology, Zhengzhou 450001, China.
Yu XiaoCollege of Environmental and Life Sciences, Murdoch University, Perth, WA 6150, Australia.
Yonglin RenCollege of Environmental and Life Sciences, Murdoch University, Perth, WA 6150, Australia.ORCID 0000-0003-4091-8812

Funding

National Natural Science Foundation of China 32272531
6 · The paper itself

Abstract

Insect symbionts and their metabolites are complex and diverse and are gradually becoming an important source of new medical materials. Some culturable symbionts from insects produce a variety of active compounds with medical potential. Among them, fatty acids, antibacterial peptides, polyene macrolides, alkaloids, and roseoflavin can inhibit the growth of human pathogenic bacteria and fungi; lipases, yeast killer toxins, reactive oxygen species, pyridines, polyethers, macrotetrolide nactins, and macrolides can kill human parasites; and peptides and polyketides can inhibit human tumors. However, due to difficulty in the culture of symbionts in vitro, difficulty in targeting bacteria to specific sites in the human body, the limited capability of symbionts to produce active metabolites in vitro, inconsistent clinical research results, adverse reactions on humans, and the development of antibiotic resistance, the application of insect symbionts and their metabolites in the medical field remains in its infancy. This paper summarizes the medical potential of insect symbionts and their metabolites and analyzes the status quo and existing problems with their medical application. Possible solutions to these problems are also proposed, with the aim of hastening the utilization of insect symbionts and their metabolites in the medical field.

Indexed as

antibioticantiparasitic activityantitumor activityinsect symbiontmedical applicationsecondary metabolite

Identifiers

PMID40429170
PMCPMC12111880

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.