Evidence map›Paper›PMID 40428750›Full record

ArticleMedicina (Kaunas, Lithuania)2025

Efficacy and Safety of Anakinra in Colchicine-Resistant or -Intolerant Familial Mediterranean Fever: A Single-Center Real-Life Experience.

Tuğba Ocak, Havva Nur Köse, Burcu Yağız, Belkıs Nihan Coşkun, Ediz Dalkılıç, Yavuz Pehlivan

Abstract read
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Observational
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tuğba OcakDepartment of Rheumatology, Bursa City Hospital, 16250 Bursa, Turkey.ORCID 0000-0002-4560-1569
Havva Nur KöseDepartment of Internal Medicine, Faculty of Medicine, Uludag University, 16285 Bursa, Turkey.
Burcu YağızDepartment of Rheumatology, Faculty of Medicine, Uludag University, 16285 Bursa, Turkey.ORCID 0000-0002-0624-1986
Belkıs Nihan CoşkunDepartment of Rheumatology, Faculty of Medicine, Uludag University, 16285 Bursa, Turkey.ORCID 0000-0003-0298-4157
Ediz DalkılıçDepartment of Rheumatology, Faculty of Medicine, Uludag University, 16285 Bursa, Turkey.
Yavuz PehlivanDepartment of Rheumatology, Faculty of Medicine, Uludag University, 16285 Bursa, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Familial Mediterranean Fever (FMF) is characterized by recurrent febrile attacks and serositis. While colchicine is the primary treatment for FMF, some patients present resistance or intolerance with respect to this drug. Anakinra-an IL-1 receptor antagonist-has demonstrated efficacy in colchicine-resistant or -intolerant FMF patients.

Indexed as

ColchicineFamilial Mediterranean FeverInterleukin 1 Receptor Antagonist ProteinAdultAntirheumatic AgentsDrug ResistanceFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeAntirheumatic AgentsColchicineInterleukin 1 Receptor Antagonist Proteinanakinracolchicine-intolerantcolchicine-resistantfamilial mediterranean fever

Identifiers

PMID40428750
PMCPMC12112854

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.