Evidence map›Paper›PMID 40428335›Full record

ArticleGenes2025

Identification of Differentially Expressed Genes in Spinal Cord Injury.

Andrew Chang, Shevanka Dias Abeyagunawardene, Xiaohang Zheng, Haiming Jin, Qingqing Wang, Jiake Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Regional Molecular Diversity in Chronic Spinal Cord Injury.Cellular and molecular neurobiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrew ChangMedical School, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0009-0009-6948-0034
Shevanka Dias AbeyagunawardeneMedical School, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0009-0003-9819-085X
Xiaohang ZhengDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Haiming JinDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Qingqing WangDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.
Jiake XuSchool of Biomedical Sciences, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0003-2021-8309

Funding

National Natural Science Foundation of China 82172424, 82372396, 82350710800, 82374470, 82472407Outstanding Youth Fund of Zhejiang Province LR22H060002Shenzhen Medical Research Fund B2302005Wenzhou Major Science and Technology Innovation Project Approval Project ZY2022007Zhejiang Medical and Health Science and Technology Plan Project 2022RC210, 2021KY212
6 · The paper itself

Abstract

backgroundSpinal cord injury (SCI) remains a profound medical challenge, with limited therapeutic options available. Studies focusing on individual molecular markers have limitations in addressing the complex disease process.

methodsThis study utilizes RNA-sequencing (RNA-seq) to investigate the differentially expressed genes (DEGs) in spinal cord tissue from a rat SCI model at 1 and 21 days post-injury (dpi). After data processing and analysis, a series of biological pathway enrichment analyses were performed using online tools DAVID and GSEA. Interactions among the enriched genes were studied using Cytoscape software to visualize protein-protein interaction networks.

resultsOur analysis identified 595 DEGs, with 399 genes significantly upregulated and 196 significantly downregulated at both time points.

conclusionsOur findings highlight complex immune and autoimmune responses that contribute to ongoing inflammation and tissue damage post-SCI, underscoring new avenues for therapeutic interventions targeting these molecular processes.

Indexed as

Spinal Cord InjuriesTranscriptomeAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 MoleculeDisease Models, AnimalGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksProtein Interaction MapsRatsRats, Sprague-DawleySpinal CordAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 MoleculeCD68 protein, ratautoimmune responsedifferentially expressed genesimmune responseinflammationmyelinRNA-seqspinal cord injury

Identifiers

PMID40428335
PMCPMC12111553

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.