Evidence map›Paper›PMID 40428146›Full record

ArticleBioengineering (Basel, Switzerland)2025

Transforming Bone Tunnel Evaluation in Anterior Cruciate Ligament Reconstruction: Introducing a Novel Deep Learning System and the TB-Seg Dataset.

Ke Xie, Mingqian Yu, Jeremy Ho-Pak Liu, Qixiang Ma, Limin Zou, Gene Chi-Wai Man, Jiankun Xu, Patrick Shu-Hang Yung, Zheng Li, Michael Tim-Yun Ong

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ke XieDepartment of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Mingqian YuDepartment of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Jeremy Ho-Pak LiuDepartment of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Qixiang MaDepartment of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-6351-3853
Limin ZouDepartment of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Gene Chi-Wai ManDepartment of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-8608-9688
Jiankun XuDepartment of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Patrick Shu-Hang YungDepartment of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Zheng LiDepartment of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Michael Tim-Yun OngDepartment of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-4460-9286

Funding

University Grants Committee 14203019, 14202820, 14214322
6 · The paper itself

Abstract

Evaluating bone tunnels is crucial for assessing functional recovery after anterior cruciate ligament reconstruction. Conventional methods are imprecise, time-consuming, and labor-intensive. This study introduces a novel deep learning-based system for accurate bone tunnel segmentation and assessment. The system has two primary stages. Firstly, the ResNet50-Unet network is employed to capture the bone tunnel area in each slice. Subsequently, in the bone texture analysis, the open-source software 3D Slicer is leveraged to execute three-dimensional reconstruction based on the segmented outcomes from the previous stage. The ResNet50-Unet network was trained and validated using a newly developed dataset named tunnel bone segmentation (TB-Seg). The outcomes reveal commendable performance metrics, with mean intersection over union (mIoU), mean average precision (mAP), precision, and recall on the validation set reaching 76%, 85%, 88%, and 85%, respectively. To assess the robustness of our innovative bone texture system, we conducted tests on a cohort of 24 patients, successfully extracting bone volume/total volume, trabecular thickness, trabecular separation, trabecular number, and volumetric information. The system excels with substantial significance in facilitating the subsequent analysis of the intricate interplay between bone tunnel characteristics and the postoperative recovery trajectory after anterior cruciate ligament reconstruction. Furthermore, in our five randomly selected cases, clinicians utilizing our system completed the entire analytical workflow in a mere 357-429 s, representing a substantial improvement compared to the conventional duration exceeding one hour.

Indexed as

anterior cruciate ligament reconstructiondeep learningsegmentationtunnel bone analysis system

Identifiers

PMID40428146
PMCPMC12108582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.